Wang Zhenghua, Wang Xiaoyu, Gao Yu, Wang Yuanyuan, Xu Minghao, Han Qiuyue, Zhao Xinhan
Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China; Department of Medical Oncology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121004, China.
Department of Medical Oncology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121004, China.
Int Immunopharmacol. 2020 Sep;86:106756. doi: 10.1016/j.intimp.2020.106756. Epub 2020 Jul 10.
Interleukin 7 receptor (IL-7R) is a member of the type I cytokine receptor family, which affects the occurrence of various tumors by forming a signaling complex with its ligand Interleukin 7 (IL-7). This study aimed to explore the potential relationships of IL-7R polymorphisms with breast cancer susceptibility in the Chinese Han women.
Five polymorphisms of IL-7R gene (rs969129, rs10213865, rs10053847, rs118137916, and rs6451231) form 553 patients and 550 healthy individuals among the Chinese Han women were genotyped using Agena MassARRAY platform. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated to evaluate the relationship.
The resulted of this study showed that rs10213865 was related to an increased breast cancer risk in allele (P = 0.045), dominant (P = 0.040), and log-additive (P = 0.029) models. As for rs969129, an increased risk of breast cancer was found in the allele (P = 0.018), co-dominant (P = 0.017), recessive (P = 0.034), and additive (P = 0.019) models. Rs6451231 was related to an increased risk of breast cancer under allele (P = 0.018), co-dominant (P = 0.021), and log-additive (P = 0.019) models. Age stratified analysis revealed that rs6451231 could enhance risk of breast cancer among the individuals older than 52 years. Furthermore, there was a significant correlation between haplotype CGAG and the decreased risk of breast cancer (P = 0.010).
This study firstly proved that IL-7R polymorphisms were significantly correlated with an increased susceptibility of breast cancer in the Chinese Han women.
白细胞介素7受体（IL-7R）是I型细胞因子受体家族的成员，它通过与其配体白细胞介素7（IL-7）形成信号复合物来影响各种肿瘤的发生。本研究旨在探讨中国汉族女性中IL-7R基因多态性与乳腺癌易感性之间的潜在关系。
使用Agena MassARRAY平台对553例中国汉族女性乳腺癌患者和550例健康个体的IL-7R基因的5个多态性位点（rs969129、rs10213865、rs10053847、rs118137916和rs6451231）进行基因分型。计算优势比（OR）和95%置信区间（95%CI）以评估其关系。
本研究结果显示，rs10213865在等位基因（P = 0.045）、显性（P = 0.040）和对数加性（P = 0.029）模型中与乳腺癌风险增加相关。对于rs969129，在等位基因（P = 0.018）、共显性（P = 0.017）、隐性（P = 0.034）和加性（P = 0.019）模型中发现乳腺癌风险增加。rs6451231在等位基因（P = 0.018）、共显性（P = 0.021）和对数加性（P = 0.019）模型下与乳腺癌风险增加相关。年龄分层分析显示，rs6451231可增加52岁以上个体患乳腺癌的风险。此外，单倍型CGAG与乳腺癌风险降低显著相关（P = 0.010）。
本研究首次证明IL-7R基因多态性与中国汉族女性乳腺癌易感性增加显著相关。
