生长抑素的生理作用。生长抑素抗血清处理的大鼠胰岛释放胰岛素。

Physiologic role of somatostatin. Insulin release from rat islets treated by somatostatin antiserum.

作者信息

Taniguchi H, Utsumi M, Hasegawa M, Kobayashi T, Watanabe Y, Murakami K, Seki M, Tsutou A, Makimura H, Sakoda M, Baba S

出版信息

Diabetes. 1977 Jul;26(7):700-2. doi: 10.2337/diab.26.7.700.

DOI:10.2337/diab.26.7.700

Abstract

In order to clarify the physiologic role of somatostatin in insulin release, rat pancreatic islets treated by somatostatin antiserum were incubated in media containing various concentrations of glucose. Insulin release from antiserum-treated islets was significantly elevated above that from nontreated ones at 3.3 and 8.3 mM glucose, while the former was not different from the latter at 16.7 mM glucose. It is suggested that somatostatin plays an important role in the regulation of insulin release in the physiologic range of glucose concentration.

摘要

为了阐明生长抑素在胰岛素释放中的生理作用，将经生长抑素抗血清处理的大鼠胰岛置于含有不同浓度葡萄糖的培养基中进行孵育。在葡萄糖浓度为3.3 mM和8.3 mM时，经抗血清处理的胰岛释放的胰岛素明显高于未处理的胰岛，而在葡萄糖浓度为16.7 mM时，前者与后者没有差异。这表明生长抑素在葡萄糖浓度的生理范围内对胰岛素释放的调节中起重要作用。