Azuma T, Kawai T, Inokuchi H, Kawai K
Gastroenterol Jpn. 1986 Oct;21(5):459-64. doi: 10.1007/BF02774628.
Gastrin release was significantly stimulated by the cholinergic agent carbachol at doses of 10(-4) M, 10(-5) M, and 10(-6) M. Peak stimulation was observed at 10(-5) M. Gastrin release was also significantly stimulated by bombesin at a dose of 10(-8) M, and 10(-6) M atropine which abolished the effect of carbachol in stimulating gastrin release had no effect on the bombesin-stimulated gastrin release. In addition, anti-somatostatin antiserum significantly stimulated gastrin release. These findings suggest that gastrin release is regulated by cholinergic and noncholinergic neurons the latter being thought to be a bombesin-containing neuron, and that antral somatostatin exerts a continuous restraint on gastrin release by the paracrine mechanism.
在剂量为10⁻⁴M、10⁻⁵M和10⁻⁶M时，胆碱能药物卡巴胆碱显著刺激胃泌素释放。在10⁻⁵M时观察到最大刺激作用。蛙皮素在剂量为10⁻⁸M时也显著刺激胃泌素释放，而10⁻⁶M阿托品可消除卡巴胆碱刺激胃泌素释放的作用，但对蛙皮素刺激的胃泌素释放没有影响。此外，抗生长抑素抗血清显著刺激胃泌素释放。这些发现表明，胃泌素释放受胆碱能和非胆碱能神经元调节，后者被认为是含蛙皮素的神经元，并且胃窦生长抑素通过旁分泌机制对胃泌素释放持续发挥抑制作用。
