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ALKBH1 deficiency leads to loss of homeostasis in human diploid somatic cells.

作者信息

Li Hongyu, Wu Zeming, Liu Xiaoqian, Zhang Sheng, Ji Qianzhao, Jiang Xiaoyu, Liu Zunpeng, Wang Si, Qu Jing, Zhang Weiqi, Song Moshi, Song Eli, Liu Guang-Hui

机构信息

National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.

University of Chinese Academy of Sciences, Beijing, 100049, China.

出版信息

Protein Cell. 2020 Sep;11(9):688-695. doi: 10.1007/s13238-020-00744-4.

DOI:10.1007/s13238-020-00744-4
PMID:32661925
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7452965/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a33f/7452965/d81ba5a6ad07/13238_2020_744_Fig2a_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a33f/7452965/11ee577c5cf1/13238_2020_744_Fig1a_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a33f/7452965/d81ba5a6ad07/13238_2020_744_Fig2a_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a33f/7452965/11ee577c5cf1/13238_2020_744_Fig1a_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a33f/7452965/d81ba5a6ad07/13238_2020_744_Fig2a_HTML.jpg

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1
ALKBH1 deficiency leads to loss of homeostasis in human diploid somatic cells.ALKBH1基因缺陷导致人类二倍体体细胞内稳态失衡。
Protein Cell. 2020 Sep;11(9):688-695. doi: 10.1007/s13238-020-00744-4.
2
Characterization of human AlkB homolog 1 produced in mammalian cells and demonstration of mitochondrial dysfunction in ALKBH1-deficient cells.在哺乳动物细胞中产生的人类AlkB同源物1的特性鉴定以及ALKBH1缺陷细胞中线粒体功能障碍的证明。
Biochem Biophys Res Commun. 2018 Jan 1;495(1):98-103. doi: 10.1016/j.bbrc.2017.10.158. Epub 2017 Oct 31.
3
Telencephalon-specific Alkbh1 conditional knockout mice display hippocampal atrophy and impaired learning.脑特异性 Alkbh1 条件性敲除小鼠表现出海马萎缩和学习能力受损。
FEBS Lett. 2021 Jun;595(12):1671-1680. doi: 10.1002/1873-3468.14098. Epub 2021 May 19.
4
ALKBH1 is a histone H2A dioxygenase involved in neural differentiation.ALKBH1 是一种组蛋白 H2A 双加氧酶,参与神经分化。
Stem Cells. 2012 Dec;30(12):2672-82. doi: 10.1002/stem.1228.
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Mitochondrial Alkbh1 localizes to mtRNA granules and its knockdown induces the mitochondrial UPR in humans and .线粒体 AlkB 同源物 1 定位于 mtRNA 颗粒,其敲低在人和 中诱导线粒体未折叠蛋白反应。
J Cell Sci. 2019 Oct 1;132(19):jcs223891. doi: 10.1242/jcs.223891.
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Biochemical Characterization of AP Lyase and mA Demethylase Activities of Human AlkB Homologue 1 (ALKBH1).人烷基化修复蛋白同源物1(ALKBH1)的AP裂解酶和mA去甲基酶活性的生化特性
Biochemistry. 2017 Apr 4;56(13):1899-1910. doi: 10.1021/acs.biochem.7b00060. Epub 2017 Mar 21.
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Alkbh1-mediated DNA N6-methyladenine modification regulates bone marrow mesenchymal stem cell fate during skeletal aging.Alkbh1 介导的 DNA N6-甲基腺嘌呤修饰调节骨骼衰老过程中骨髓间充质干细胞的命运。
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N-methyladenine demethylase ALKBH1 inhibits the differentiation of skeletal muscle.N6-甲基腺嘌呤去甲基酶 ALKBH1 抑制骨骼肌的分化。
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ALKBH1 is an RNA dioxygenase responsible for cytoplasmic and mitochondrial tRNA modifications.ALKBH1是一种RNA双加氧酶,负责细胞质和线粒体转运RNA的修饰。
Nucleic Acids Res. 2017 Jul 7;45(12):7401-7415. doi: 10.1093/nar/gkx354.
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The stress specific impact of ALKBH1 on tRNA cleavage and tiRNA generation.ALKBH1 对 tRNA 切割和 tiRNA 生成的应激特异性影响。
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Extracellular matrix stiffness reduces DNA 6 ma level to facilitate colorectal cancer progression via disrupting P53 binding to CDKN1A promoter.细胞外基质硬度通过破坏P53与CDKN1A启动子的结合降低DNA 6mA水平,以促进结直肠癌进展。
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ALKBH1 drives tumorigenesis and drug resistance via tRNA decoding reprogramming and codon-biased translation.ALKBH1通过tRNA解码重编程和密码子偏向性翻译驱动肿瘤发生和耐药性。
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CRISPR screening uncovers nucleolar RPL22 as a heterochromatin destabilizer and senescence driver.

本文引用的文献

1
N-methyladenine is incorporated into mammalian genome by DNA polymerase.N-甲基腺嘌呤通过DNA聚合酶掺入哺乳动物基因组中。
Cell Res. 2021 Jan;31(1):94-97. doi: 10.1038/s41422-020-0317-6. Epub 2020 Apr 30.
2
No evidence for DNA -methyladenine in mammals.哺乳动物中不存在 DNA -甲基腺嘌呤的证据。
Sci Adv. 2020 Mar 18;6(12):eaay3335. doi: 10.1126/sciadv.aay3335. eCollection 2020 Mar.
3
The origin of genomic N-methyl-deoxyadenosine in mammalian cells.哺乳动物细胞中基因组 N-甲基脱氧腺苷的起源。
CRISPR 筛选揭示核仁 RPL22 作为异染色质稳定剂和衰老驱动因子。
Nucleic Acids Res. 2024 Oct 28;52(19):11481-11499. doi: 10.1093/nar/gkae740.
4
Structural Basis of Nucleic Acid Recognition and 6mA Demethylation by NMAD-1A.NMAD-1A 通过识别核酸和 6mA 去甲基化的结构基础。
Int J Mol Sci. 2024 Jan 5;25(2):686. doi: 10.3390/ijms25020686.
5
BMAL1 moonlighting as a gatekeeper for LINE1 repression and cellular senescence in primates.BMAL1 兼职作为 LINE1 抑制和灵长类细胞衰老的守门员。
Nucleic Acids Res. 2022 Apr 8;50(6):3323-3347. doi: 10.1093/nar/gkac146.
6
Hyperthermia differentially affects specific human stem cells and their differentiated derivatives.热疗对特定人类干细胞及其分化衍生物有不同影响。
Protein Cell. 2022 Aug;13(8):615-622. doi: 10.1007/s13238-021-00887-y.
7
The exploration of N6-deoxyadenosine methylation in mammalian genomes.哺乳动物基因组中 N6-去氧腺嘌呤甲基化的研究。
Protein Cell. 2021 Oct;12(10):756-768. doi: 10.1007/s13238-021-00866-3. Epub 2021 Aug 17.
8
SIRT3 consolidates heterochromatin and counteracts senescence.SIRT3 巩固异染色质并抵抗衰老。
Nucleic Acids Res. 2021 May 7;49(8):4203-4219. doi: 10.1093/nar/gkab161.
9
FOXO3-engineered human mesenchymal progenitor cells efficiently promote cardiac repair after myocardial infarction.经FOXO3基因工程改造的人间充质祖细胞能有效促进心肌梗死后的心脏修复。
Protein Cell. 2021 Feb;12(2):145-151. doi: 10.1007/s13238-020-00779-7.
Nat Chem Biol. 2020 Jun;16(6):630-634. doi: 10.1038/s41589-020-0504-2. Epub 2020 Mar 23.
4
Mammalian ALKBH1 serves as an N-mA demethylase of unpairing DNA.哺乳动物 ALKBH1 作为未配对 DNA 的 N-mA 去甲基酶。
Cell Res. 2020 Mar;30(3):197-210. doi: 10.1038/s41422-019-0237-5. Epub 2020 Feb 12.
5
Structural basis of nucleic acid recognition and 6mA demethylation by human ALKBH1.人源ALKBH1对核酸识别及6mA去甲基化的结构基础
Cell Res. 2020 Mar;30(3):272-275. doi: 10.1038/s41422-019-0233-9. Epub 2020 Feb 12.
6
The ageing epigenome and its rejuvenation.衰老的表观基因组及其年轻化。
Nat Rev Mol Cell Biol. 2020 Mar;21(3):137-150. doi: 10.1038/s41580-019-0204-5. Epub 2020 Feb 4.
7
N-methyladenine DNA Modification in Glioblastoma.神经胶质母细胞瘤中的 N-甲基腺嘌呤 DNA 修饰。
Cell. 2018 Nov 15;175(5):1228-1243.e20. doi: 10.1016/j.cell.2018.10.006. Epub 2018 Nov 1.
8
N-Methyladenine DNA Modification in the Human Genome.N-甲基腺嘌呤 DNA 修饰在人类基因组中。
Mol Cell. 2018 Jul 19;71(2):306-318.e7. doi: 10.1016/j.molcel.2018.06.015. Epub 2018 Jul 12.
9
ALKBH1 is an RNA dioxygenase responsible for cytoplasmic and mitochondrial tRNA modifications.ALKBH1是一种RNA双加氧酶,负责细胞质和线粒体转运RNA的修饰。
Nucleic Acids Res. 2017 Jul 7;45(12):7401-7415. doi: 10.1093/nar/gkx354.
10
ALKBH1-Mediated tRNA Demethylation Regulates Translation.ALKBH1介导的tRNA去甲基化调控翻译过程。
Cell. 2016 Oct 20;167(3):816-828.e16. doi: 10.1016/j.cell.2016.09.038. Epub 2016 Oct 13.