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FOXO3-engineered human mesenchymal progenitor cells efficiently promote cardiac repair after myocardial infarction.

作者信息

Lei Jinghui, Wang Si, Kang Wang, Chu Qun, Liu Zunpeng, Sun Liang, Ji Yun, Esteban Concepcion Rodriguez, Yao Yan, Belmonte Juan Carlos Izpisua, Chan Piu, Liu Guang-Hui, Zhang Weiqi, Song Moshi, Qu Jing

机构信息

Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, 100053, China.

State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.

出版信息

Protein Cell. 2021 Feb;12(2):145-151. doi: 10.1007/s13238-020-00779-7.

DOI:10.1007/s13238-020-00779-7
PMID:32809106
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7862469/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3ec/7862469/602eccbe0f37/13238_2020_779_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3ec/7862469/ad9e01a9bcac/13238_2020_779_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3ec/7862469/602eccbe0f37/13238_2020_779_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3ec/7862469/ad9e01a9bcac/13238_2020_779_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3ec/7862469/602eccbe0f37/13238_2020_779_Fig2_HTML.jpg

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Protein Cell. 2020 Sep;11(9):688-695. doi: 10.1007/s13238-020-00744-4.
2
A single-cell transcriptomic landscape of primate arterial aging.灵长类动物动脉衰老的单细胞转录组图谱。
Nat Commun. 2020 May 5;11(1):2202. doi: 10.1038/s41467-020-15997-0.
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Understanding and leveraging cell metabolism to enhance mesenchymal stem cell transplantation survival in tissue engineering and regenerative medicine applications.
Nat Commun. 2025 Mar 27;16(1):3012. doi: 10.1038/s41467-025-58301-8.
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A biomarker framework for cardiac aging: the Aging Biomarker Consortium consensus statement.心脏衰老的生物标志物框架：衰老生物标志物联盟共识声明。
Life Med. 2023 Sep 27;2(5):lnad035. doi: 10.1093/lifemedi/lnad035. eCollection 2023 Oct.
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Genetic enhancement: an avenue to combat aging-related diseases.基因增强：对抗衰老相关疾病的一条途径。
Life Med. 2022 Nov 22;1(3):307-318. doi: 10.1093/lifemedi/lnac054. eCollection 2022 Dec.
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Protein Cell. 2025 May 28;16(5):365-373. doi: 10.1093/procel/pwaf004.
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A Genome-Wide CRISPR/Cas9 Screen Identifies Regulatory Genes for Stem Cell Aging.全基因组CRISPR/Cas9筛选鉴定干细胞衰老的调控基因。
Methods Mol Biol. 2025;2960:159-170. doi: 10.1007/7651_2024_566.
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L1 drives IFN in senescent cells and promotes age-associated inflammation.L1 在衰老细胞中驱动 IFN 并促进与年龄相关的炎症。
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