Department of Dietetics and Nutrition, University of Kansas Medical Center, Kansas City, KS, USA.
University of Kansas Medical Center, Hoglund Brain Imaging Center, Kansas City, KS, USA.
J Dev Orig Health Dis. 2021 Jun;12(3):354-356. doi: 10.1017/S2040174420000653. Epub 2020 Jul 14.
Maternal obesity is an established risk factor for poor infant neurodevelopmental outcomes; however, the link between maternal weight and fetal development in utero is unknown. We investigated whether maternal obesity negatively influences fetal autonomic nervous system (ANS) development. Fetal heart rate variability (HRV) is an index of the ANS that is associated with neurodevelopmental outcomes in the infant. Maternal-fetal magnetocardiograms were recorded using a fetal biomagnetometer at 36 weeks (n = 46). Fetal HRV was represented by the standard deviation of sinus beat-to-beat intervals (SDNN). Maternal weight was measured at enrollment (12-20 weeks) and 36 weeks. The relationships between fetal HRV and maternal weight at both time points were modeled using adjusted ordinary least squares regression models. Higher maternal weight at enrollment and 36 weeks were associated with lower fetal HRV, an indicator of poorer ANS development. Further study is needed to better understand how maternal obesity influences fetal autonomic development and long-term neurodevelopmental outcomes.
母亲肥胖是婴儿神经发育不良的既定危险因素；然而，母亲体重与子宫内胎儿发育之间的联系尚不清楚。我们研究了母亲肥胖是否会对胎儿自主神经系统 (ANS) 的发育产生负面影响。胎儿心率变异性 (HRV) 是 ANS 的一个指标，与婴儿的神经发育结果相关。在 36 周时，使用胎儿生物磁强计记录了母婴的磁心电图（n = 46）。胎儿 HRV 由窦性心跳间隔的标准差 (SDNN) 表示。在入组时（12-20 周）和 36 周时测量了母亲的体重。使用调整后的普通最小二乘回归模型对胎儿 HRV 与两个时间点的母亲体重之间的关系进行了建模。入组和 36 周时母亲体重较高与胎儿 HRV 较低有关，这是 ANS 发育较差的一个指标。需要进一步研究以更好地了解母亲肥胖如何影响胎儿自主神经发育和长期神经发育结果。
