Muzasti Riri Andri, Hariman Herman, Rahmi Daulay Elvita
Division of Nephrology and Hypertension, Department of Internal Medicine, Universitas Sumatera Utara, Medan, Indonesia.
Department of Clinical Pathology, Universitas Sumatera Utara, Medan, Indonesia.
Med Glas (Zenica). 2020 Aug 1;17(2):346-351. doi: 10.17392/1172-20.
Aim To investigate the relationship between IL-6 concentration and the risk of carotid artery calcification in chronic kidney disease patients with dialysis (CKD-5D). Methods This analytic observational cross-sectional study includes 95 clinically stable patients who underwent regular haemodialysis for at least three months at Rasyida Renal Hospital Medan, Indonesia. Serum IL-6 level was measured using the enzyme-linked immunosorbent assay (ELISA). Carotid artery calcification was determined by measuring Carotid Intima-Media Thickness (CIMT) using Real-Time B-mode ultrasound. Results There were 53 males (55.8%) of the total samples with the mean duration of haemodialysis of 81.28±67.40 months. Ultrasound examination showed that 28 samples (29.5%) had carotid artery calcification. Statistical test significantly showed that patients with IL-6 ≥81.1 pg/mL were more likely to have carotid artery calcification with an increased risk of 12.92 times (95% CI: 5.54-30.12) compared to the group of patients who had IL-6 level <81.1 pg/mL (p <0.001). Conclusion This study proves that a high level of IL-6 can increase the risk of carotid artery calcification in CKD-5D patients.
目的 探讨慢性肾脏病透析患者（CKD-5D）白细胞介素-6（IL-6）浓度与颈动脉钙化风险之间的关系。方法 本分析性观察性横断面研究纳入了95例临床稳定的患者，这些患者在印度尼西亚棉兰Rasyida肾脏医院接受了至少三个月的定期血液透析。采用酶联免疫吸附测定（ELISA）法检测血清IL-6水平。通过实时B型超声测量颈动脉内膜中层厚度（CIMT）来确定颈动脉钙化情况。结果 在全部样本中，有53名男性（55.8%），血液透析平均时长为81.28±67.40个月。超声检查显示，28个样本（29.5%）存在颈动脉钙化。统计学检验显著表明，与IL-6水平<81.1 pg/mL的患者组相比，IL-6≥81.1 pg/mL的患者更易发生颈动脉钙化，风险增加12.92倍（95%置信区间：5.54 - 30.12）（p<0.001）。结论 本研究证明，高水平的IL-6会增加CKD-5D患者颈动脉钙化的风险。
