Salama Daryoush Saedi, Narooinejad Minoo, Saffari Samira, Khak Mohammad
Department of Radiology, Hasheminejad Kidney Center, School of Medicine, Iran.
Exp Clin Transplant. 2011 Feb;9(1):26-31.
Cardiovascular events are a major cause of mortality and morbidity of chronic renal failure causing 40% to 50% of all deaths in these patients. The intima-media thickness of the common carotid artery is used to predict atherosclerosis. To assess the effect of early renal transplant on the vascular atherosclerosis, we compared the common carotid intima-media thickness between dialysis and transplant patients.
In a cross-sectional study, 75 kidney transplant recipients and 75 dialysis patients were assessed in a subspecialized renal and urethral diseases center from April 2008 to March 2010. Demographic characteristics, smoking history, and information on comorbid and kidney diseases were recorded through a checklist. The common carotid intima-media thickness was measured using ultrasonography. Spearman's rank correlation coefficient was used to find any correlation between duration of dialysis and intimamedia thickness.
In all, 79 patients (53%) were male. The mean age (SD) of dialysis and transplant patients was 55 ± 11 and 51 ± 15 years. The 2 groups had no statistically significant sex or age differences (P > .05). Considering all patients, 54 (36%) had a history of hypertension, 30 (20%) had a history of diabetes mellitus, 15 (10%) had a history of hyperlipidemia, and 41 (27.3%) had a history of smoking. There were no significant differences between the 2 groups when these variables were considered (P > .05). The mean thickness of the common carotid intima-media was 1.2 mm (0.35 mm) in the dialysis patients, which was higher compared with 0.73 mm (0.18 mm) in the transplanted group (P < .001). There was a significant correlation between duration of dialysis and intima-media thickness (P < .001, r=0.882) in the dialysis group.
Common carotid intima-media thickness in dialysis patients is significantly higher compared with kidney transplant recipients. Carotid intima-media thickness increases by prolongation of dialysis duration.
心血管事件是慢性肾衰竭患者死亡和发病的主要原因，导致这些患者中40%至50%的死亡。颈总动脉内膜中层厚度用于预测动脉粥样硬化。为了评估早期肾移植对血管动脉粥样硬化的影响，我们比较了透析患者和移植患者的颈总动脉内膜中层厚度。
在一项横断面研究中，2008年4月至2010年3月期间，在一家专科肾脏和尿道疾病中心对75名肾移植受者和75名透析患者进行了评估。通过清单记录人口统计学特征、吸烟史以及合并症和肾脏疾病信息。使用超声测量颈总动脉内膜中层厚度。采用Spearman等级相关系数来寻找透析时间与内膜中层厚度之间的相关性。
共有79名患者（53%）为男性。透析患者和移植患者的平均年龄（标准差）分别为55±11岁和51±15岁。两组在性别或年龄上无统计学显著差异（P>.05）。在所有患者中，54名（36%）有高血压病史，30名（20%）有糖尿病病史，15名（10%）有高脂血症病史，41名（27.3%）有吸烟史。在考虑这些变量时，两组之间无显著差异（P>.05）。透析患者颈总动脉内膜中层的平均厚度为1.2毫米（0.35毫米），高于移植组的0.73毫米（0.18毫米）（P<.001）。透析组中透析时间与内膜中层厚度之间存在显著相关性（P<.001，r=0.882）。
透析患者的颈总动脉内膜中层厚度显著高于肾移植受者。随着透析时间的延长，颈动脉内膜中层厚度增加。
