Department of Internal Medicine, Institute of Medical Sciences, Medical College of Rzeszow University, Rzeszow, Poland.
Department of Biochemistry, Institute of Medical Sciences, Medical College of Rzeszow University, Rzeszow, Poland.
Biomarkers. 2021 May;26(3):185-195. doi: 10.1080/1354750X.2020.1794043. Epub 2021 Feb 10.
Rheumatoid arthritis is a chronic, autoimmune connective tissue disease. In addition to joint involvement, extra-articular changes and organ complications also occur in the course of the disease. Untreated disease leads to disability and premature death. Therefore, it is important to recognise and begin treatment early. Based on the presence of rheumatoid factor and antibodies against citrullinated peptides, we can distinguish two forms of the disease: seropositive and seronegative. Research continues to elucidate the mechanisms of the onset of the disease, as well as to uncover factors that induce and influence the activity of the disease. The presence of markers that initially appear and affect the course of the disease can potentially aid in patient treatment. In this article, we have collected biomarkers of rheumatoid arthritis that are well understood as well as those that have been recently described.
类风湿关节炎是一种慢性、自身免疫性结缔组织疾病。除关节受累外，疾病过程中还会发生关节外改变和器官并发症。未经治疗的疾病会导致残疾和过早死亡。因此，早期识别和开始治疗非常重要。根据类风湿因子和抗瓜氨酸肽抗体的存在，我们可以将疾病分为两种形式：血清阳性和血清阴性。研究不断阐明疾病发作的机制，并揭示诱导和影响疾病活动的因素。最初出现并影响疾病进程的标志物的存在可能有助于患者的治疗。本文收集了已充分了解的类风湿关节炎生物标志物以及最近描述的生物标志物。
