Podgórska Dominika, Cieśla Marek, Kolarz Bogdan
Department of Internal Diseases, Institute of Medical Sciences, College of Medical Sciences, University of Rzeszow, 35-959 Rzeszow, Poland.
College of Medical Sciences, University of Rzeszow, 35-959 Rzeszow, Poland.
J Clin Med. 2022 Aug 9;11(16):4664. doi: 10.3390/jcm11164664.
Rheumatoid arthritis (RA) is a chronic autoimmune disease that, when improperly treated, leads to disability in patients. Various factors that may cause the development and activity of RA are being considered. Epigenetic factors are also receiving increasing attention. In our study, we analyzed the association between FCER1G gene methylation and RA activity. We conducted our study in 50 RA patients and 24 controls. The patients were divided into two groups in terms of high disease activity and remission. Quantitative real-time methylation-specific PCR was used to analyze the methylation status of the investigated genes. We observed that RA patients have lower levels of methylation of the FCER1G gene compared to controls, but we did not find any difference in the methylation status of this gene between patients with high disease activity and remission. The results of this study suggest that FCER1G gene methylation may be a new potential epigenetic marker of RA that is independent of disease activity.
类风湿性关节炎（RA）是一种慢性自身免疫性疾病，若治疗不当会导致患者残疾。目前正在考虑各种可能导致RA发生和活动的因素。表观遗传因素也越来越受到关注。在我们的研究中，我们分析了FCER1G基因甲基化与RA活动之间的关联。我们对50例RA患者和24例对照进行了研究。根据疾病高活动度和缓解情况将患者分为两组。采用定量实时甲基化特异性PCR分析所研究基因的甲基化状态。我们观察到，与对照组相比，RA患者的FCER1G基因甲基化水平较低，但在疾病高活动度患者和缓解患者之间，该基因的甲基化状态未发现任何差异。本研究结果表明，FCER1G基因甲基化可能是一种独立于疾病活动度的新的潜在RA表观遗传标志物。
