Department of Oral and Maxillofacial Medicine, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
J Oral Implantol. 2021 Feb 1;47(1):88-90. doi: 10.1563/aaid-joi-D-19-00341.
At present, dental implants are used more than before, and their high success rate is attributed to sufficient osseointegration, which depends on prosthetic-, implant-, and patient-related factors. The quality and quantity of bone and the host response are the main patient-related factors. Vitamin D3 affects bone metabolism by stimulating both osteoclasts and osteoblasts. This study aimed to review the human studies on the efficacy of vitamin D3 for dental implant osseointegration. Search of the literature yielded only 4 studies on human models, of which 2 showed the optimal efficacy of vitamin D3 for dental implant osseointegration, whereas the remaining 2 did not report any positive effect. However, this finding may be related to the small sample size of the vitamin D3-deficient group, which can compromise statistical analyses. In conclusion, vitamin D3 seems to be effective for dental implant osseointegration, although further research is required on human models.
目前，种植牙的应用比以往更为广泛，其高成功率归因于充分的骨整合，而这取决于修复体、种植体和患者相关因素。骨的质量和数量以及宿主反应是主要的患者相关因素。维生素 D3 通过刺激破骨细胞和成骨细胞来影响骨代谢。本研究旨在综述维生素 D3 对种植牙骨整合疗效的人体研究。文献检索仅发现 4 项人体模型研究，其中 2 项表明维生素 D3 对种植牙骨整合具有最佳疗效，而其余 2 项未报告任何积极效果。然而，这一发现可能与维生素 D3 缺乏组的样本量较小有关，这可能会影响统计分析。总之，维生素 D3 似乎对种植牙骨整合有效，但仍需要在人体模型上进行进一步研究。
