Nawojski A, Nawrocka W, Liszkiewicz H, Krzywosiński L, Bogdal M
Department of Technology of Drugs, Medical Academy, Wrocław, Poland.
Pol J Pharmacol Pharm. 1988 Mar-Apr;40(2):191-9.
A series of six compounds, 5-chloroacetyl-4-methyl-1H-tetrahydro-1,5-benzodiazepin-2-one and 5-dialkilaminoacetyl derivatives of 4-methyl-1H-tetrahydro-1,5-benzodiazepin-2-one, have been synthesized. 5-Diizobutylaminoacetyl-4-methyl-1H-tetrahydro-1,5-benzodiazepi n-2-one showed weak analgesic and antiinflammatory activity.
已合成了一系列六种化合物，即5-氯乙酰基-4-甲基-1H-四氢-1,5-苯并二氮杂䓬-2-酮以及4-甲基-1H-四氢-1,5-苯并二氮杂䓬-2-酮的5-二烷基氨基乙酰基衍生物。5-二异丁基氨基乙酰基-4-甲基-1H-四氢-1,5-苯并二氮杂䓬-2-酮表现出微弱的镇痛和抗炎活性。
