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[5-Aroyl-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepin-4-carboxylic acids: synthesis and analgesic and neurobehavioral activity].

作者信息

Massa S, Corelli F, Artico M, Mai A, Silvestri R, Pantaleoni G C, Palumbo G, Fanini D, Giorgi R

机构信息

Dipartimento di Studi Farmaceutici-Università di Roma La Sapienza.

出版信息

Farmaco. 1989 Feb;44(2):109-23.

PMID:2789054
Abstract

Reaction between 1-(2-aminomethylphenyl)-1H-pyrrole hydrochloride and methyl 2-methoxyglicolate in methanol afforded methyl 5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepin-4-carboxylate. Aroylation at the 5-position and subsequent hydrolysis of the ester function led to 5-aroyl-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepin-4-ca rboxylic acids. The pharmacological profile of these acids has been studied with regard to analgesic, antiinflammatory and neuropsychobehavioural effects.

摘要

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引用本文的文献

1
An Update on the Synthesis of Pyrrolo[1,4]benzodiazepines.吡咯并[1,4]苯并二氮杂卓合成的最新进展
Molecules. 2016 Jan 28;21(2):154. doi: 10.3390/molecules21020154.