Cancer Institute, Xuzhou Medical University, 84 Huaihai Xi Road, Quanshan, Xuzhou, Jiangsu 221002, China; Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Department of Pathology, University of Pittsburgh, S713 Scaife Hall, 3550 Terrace St, Pittsburgh, PA 15261, USA; Pittsburgh VA Medical Center, VA Pittsburgh Healthcare System, Pittsburgh, USA; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA; Department of Computational & Systems Biology, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Semin Cancer Biol. 2021 Jun;71:2-9. doi: 10.1016/j.semcancer.2020.07.004. Epub 2020 Jul 12.
Liver metastasis causes nearly half of death from solid tumors. Metastatic lesions, to the liver in particular, can become detectable years or decades after primary tumor removal, leaving an uncertain long-term prognosis in patients. Prostate cancer (PCa), a prominent metastatic dormant cancer, has the worst prognosis when found in the liver compared to other metastatic sites. These metastatic nodules display a therapy resistance in the liver pro-metastatic microenvironment; the resistance appears to be conferred by both dormancy and independent of dormancy when the nodules emerge. Within the review, the molecular underpinnings of how the liver aids and protects PCa cells seeding, colonization and resistance will be discussed.
肝脏转移导致近半数实体瘤患者死亡。转移性病变，特别是肝脏转移，在原发性肿瘤切除后数年甚至数十年才会被检测到，这使得患者的长期预后不确定。前列腺癌（PCa）是一种突出的休眠转移性癌症，与其他转移部位相比，在肝脏中发现时预后最差。这些转移性结节在肝脏促转移微环境中表现出治疗耐药性；当结节出现时，这种耐药性似乎是由休眠和休眠独立赋予的。在综述中，将讨论肝脏如何帮助和保护前列腺癌细胞播种、定植和耐药的分子基础。
