[Cellular and humoral immunity and systemic and regional fibrinolysis in patients with chronic suppurative bronchitis].

The state of cellular and humoral immunity, systemic and regional fibrinolysis was studied in 47 patients with chronic purulent bronchitis of a moderately severe and severe course. The suppression of cellular immunity, expressed in the reduction of the number and function of T-cells, the reduction of the number of theophylline-resistant cells with the unchangeable level of theophylline-sensitive lymphocytes was revealed. An additional study of O-cells made it possible to reveal an increase in the number of precursor and blocked T-cells, the prevalence of the fraction of suppressor-killer lymphocytes in T-lymphocyte subpopulation. The detected shifts lead to disturbance of T-B-cell cooperation, antibody genesis, and breakage of fibrinolysis immune regulation which determine progression of inflammatory changes in the bronchopulmonary system. Their detection and elimination form the basis of modern pathogenetic therapy of purulent forms of chronic bronchitis.