[The cellular immunity and cyclonucleotide level in the immunoregulatory cells of patients with bronchial asthma and chronic bronchitis].

The paper presents the analysis of T-cell immunity in asthmatics and bronchitis chronics. Immunodeficiency in one-third of them was characterized by thymic failure. T-cell insufficiency was registered in 50% and 37% of atopic and bacterial asthma patients, respectively, in 40% and 25% of those with chronic obstructive bronchitis and nonobstructive one, respectively. Imbalance of immunoregulatory cells in atopic asthma in 87% of relevant patients and in 37% of chronics with obstructive bronchitis was indicated by enhanced suppressor activity. In patients with bacterial asthma and chronic nonobstructive bronchitis (in 40% and 25%, respectively) helper-cell activity rose. A cAMP concentration proved reduced in helper cells and helper + suppressor subpopulations in bacterial asthma and obstructive bronchitis chronics, respectively. Atopic bronchial asthma was associated with low suppressor subpopulation. Variants of immunocorrection in the above conditions are presented for discussion.