FOM University of Applied Sciences for Economics and Management, Frankfurt, Germany.
Epidemiology, IQVIA, Main Airport Center, Unterschweinstiege 2-14, 60549 Frankfurt, Germany.
J Affect Disord. 2020 Sep 1;274:482-485. doi: 10.1016/j.jad.2020.05.074. Epub 2020 May 25.
The aim of this study was to explore rates of depression, anxiety, and adjustment and somatoform disorders in a large sample of transsexual individuals (TSI), compared with matched non-TSI cohorts from general practices in Germany.
Individuals initially documented as transsexual (index date) between January 2010 and December 2018 were identified in 468 general practices (GP) from the IMS Disease Analyzer database (IQVIA). Non-transsexual women (NTSW) and men (NTSM) were matched (1:1) with transsexual individuals by age, index year, and physician. The main outcome measure was the prevalence of depression, anxiety, and adjustment and somatoform disorders among TSI compared to NTSW and NTSM.
A total of 535 TSI, 535 NTSW, and 535 NTSM were analyzed (mean age in each group was 35 years). Depression was documented in 20% of TSI versus 7.7% of NTSW and 5.5% of NTSM (p < 0.001), reaction to severe stress and adjustment disorders in 10% of TSI versus 4.3% of NTSW and 2.9% of NTSM (p < 0.001), somatoform disorders in 9.7% of TSI versus 5.8% of NTSW and 5.8% of NTSM (p 0.016), and anxiety disorders in 5.8% of TSI versus 1.9% of NTSW and 1.6% of NTSM, (p < 0.001).
Our findings indicate a need to promote TSI mental health. Furthermore, primary care physicians and psychiatrists should be aware of the importance of detecting and treating mental disorders in TSI and thereby improve their quality of life.
本研究旨在探讨大量跨性别个体（TSI）与德国普通诊所匹配的非 TSI 队列相比，抑郁、焦虑、适应和躯体形式障碍的发生率。
从 IQVIA 的 IMS Disease Analyzer 数据库中，确定了 468 家普通诊所（GP）中从 2010 年 1 月至 2018 年 12 月期间首次记录为跨性别者（索引日期）的个体。非跨性别女性（NTSW）和男性（NTSM）与跨性别个体按年龄、索引年和医生进行 1:1 匹配。主要结局指标是与 NTSW 和 NTSM 相比，TSI 中抑郁、焦虑、适应和躯体形式障碍的患病率。
共分析了 535 名 TSI、535 名 NTSW 和 535 名 NTSM（每组平均年龄为 35 岁）。TSI 中记录到抑郁的比例为 20%，而 NTSW 和 NTSM 中分别为 7.7%和 5.5%（p<0.001），TSI 中对严重应激和适应障碍的反应为 10%，而 NTSW 和 NTSM 中分别为 4.3%和 2.9%（p<0.001），TSI 中躯体形式障碍为 9.7%，而 NTSW 和 NTSM 中分别为 5.8%和 5.8%（p=0.016），TSI 中焦虑障碍为 5.8%，而 NTSW 和 NTSM 中分别为 1.9%和 1.6%（p<0.001）。
我们的研究结果表明，需要促进 TSI 的心理健康。此外，初级保健医生和精神科医生应意识到检测和治疗 TSI 中的精神障碍的重要性，从而提高他们的生活质量。
