Copenhagen Affective Disorders Research Centre (CADIC), Psychiatric Centre Copenhagen, Rigshospitalet; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen.
Department of Clinical Biochemistry Rigshospitalet, Copenhagen University Hospital; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen.
J Affect Disord. 2020 Sep 1;274:726-732. doi: 10.1016/j.jad.2020.05.015. Epub 2020 May 25.
The calcium binding protein S100B and brain derived neurotrophic factor (BDNF) are both biomarkers implicated in neuronal processes in the central nervous system and seem to be associated with affective disorders. Here we investigated both markers in a sample of monozygotic (MZ) twins with, at risk of and without affective disorders, aiming to evaluate whether these markers have a role as causal factors- or trait markers for affective disorders.
We measured serum S100B and plasma BDNF levels in 204 monozygotic twins (MZ) with unipolar or bipolar disorder in remission or partial remission (affected), their unaffected co-twins (high-risk) and twins with no personal or family history of affective disorder (low-risk).
No significant group differences in S100B and BDNF levels were found between the three groups. Exploratory analysis revealed that higher S100B levels were correlated with lower cognitive performance.
The cross-sectional design cannot elucidate the two neuronal biomarkers role as causal factors. We would have preferred a higher sample size in the high- and low-risk groups.
The present result did not support a role for S100B and BDNF as neither causal factors nor trait markers for affective disorders. Elevated S100B levels may associate with impaired cognition, but further studies are warranted.
钙结合蛋白 S100B 和脑源性神经营养因子（BDNF）都是中枢神经系统神经元过程中涉及的生物标志物，似乎与情感障碍有关。在这里，我们在有、无情感障碍风险的单卵双胞胎（MZ）样本中研究了这两种标志物，旨在评估这些标志物是否作为情感障碍的因果因素或特征标志物发挥作用。
我们测量了 204 名处于缓解或部分缓解期（患病）的单相或双相情感障碍的 MZ 双胞胎、未受影响的同卵双胞胎（高风险）以及无情感障碍个人或家族史的双胞胎的血清 S100B 和血浆 BDNF 水平。
三组之间 S100B 和 BDNF 水平无显著组间差异。探索性分析显示，较高的 S100B 水平与较低的认知表现相关。
横断面设计无法阐明这两种神经元生物标志物作为因果因素的作用。我们原本希望在高风险和低风险组中获得更大的样本量。
本研究结果不支持 S100B 和 BDNF 作为情感障碍的因果因素或特征标志物。S100B 水平升高可能与认知障碍有关，但需要进一步研究。
