间接艾灸治疗变应性鼻炎的有效性和安全性：一项随机对照试验的系统评价和Meta分析方案
Effectiveness and safety of indirect moxibustion for the treatment of allergic rhinitis: A protocol for systematic review and meta-analysis of RCTs.
作者信息
Yuan Ting, Fu Yong, Xiong Jun, Zhang Haifeng, Yang Jun, Wang Xue, Fan Hao, Jiang Yunfeng, Zhou Xiaohong, Liao Kai, Xu Lingling
机构信息
School of Acupuncture, Moxibustion and Tuina of Jiangxi University of Traditional Chinese Medicine.
Department of Acupuncture and Moxibustion, the Affiliated Hospital with Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
出版信息
Medicine (Baltimore). 2020 Jul 10;99(28):e20911. doi: 10.1097/MD.0000000000020911.
BACKGROUND
Allergic rhinitis (AR) is a common allergic disorder worldwide. Western medicine is not optimistic about the therapeutic effect of this disease. However, moxibustion can enhance vital energy or immunity through a great number of clinical trials. Thus, the aim of this systematic review and meta-analysis is to systematically evaluate the effectiveness and safety of indirect moxibustion for treating AR.
METHODS
We will conduct a comprehensive literature search in Medline, PubMed, Web of Science, Embase, the Cochrane Library, China National Knowledge Infrastructure Database, WanFang Database, Chinese Scientific Journal Database, and Chinese Biomedical Literature Database from inception to August 2020 without any language restriction. In addition, we will retrieve the unpublished studies and the references of initially included literature manually. Reviewers will identify studies, extract data, and assess the quality independently. The outcomes of interest include: total effective rate, total nasal symptom score, total non-nasal symptom score, rhinitis quality of life questionnaire, visual analog scale, laboratory indicators (i.e., serum levels of IgE, IgA, or IgG), and adverse events. Randomized clinical trials will be collected, methodological quality will be evaluated using the Cochrane risk-of-bias assessment tool, and the level of evidence will be rated using the Grading of Recommendations, Assessment, Development and Evaluation approach. Meta-analysis will be performed using RevMan 5.3.0 software. The heterogeneity test will be conducted between the studies, and P < .1 and I > 50% are the thresholds for the tests. We will utilize the fixed effects model or the random effects model according to the size of heterogeneity.
RESULTS
Because the review is ongoing, no results can be reported.
CONCLUSIONS
The results of this review will provide reliable evidence for effectiveness and safety of indirect moxibustion for treating AR.
ETHICS AND DISSEMINATION
Ethical approval is not required for this study. This systematic review and meta-analysis will be disseminated online and on paper to help guide clinicians.
PROSPERO REGISTRATION NUMBER
CRD42019140944.
背景
变应性鼻炎（AR）是一种全球常见的过敏性疾病。西医对该病的治疗效果并不乐观。然而，通过大量临床试验发现艾灸可增强正气或免疫力。因此，本系统评价和荟萃分析的目的是系统评价间接艾灸治疗AR的有效性和安全性。
方法
我们将对Medline、PubMed、Web of Science、Embase、Cochrane图书馆、中国知网数据库、万方数据库、中国科技期刊数据库和中国生物医学文献数据库进行全面的文献检索，检索时间从建库至2020年8月，无语言限制。此外，我们将手动检索未发表的研究以及最初纳入文献的参考文献。评价者将独立识别研究、提取数据并评估质量。感兴趣的结局包括：总有效率、总鼻症状评分、总非鼻症状评分、鼻炎生活质量问卷、视觉模拟量表、实验室指标（即血清IgE、IgA或IgG水平）以及不良事件。将收集随机临床试验，使用Cochrane偏倚风险评估工具评估方法学质量，并使用推荐分级、评估、制定与评价方法对证据水平进行分级。将使用RevMan 5.3.0软件进行荟萃分析。将在各研究之间进行异质性检验，检验阈值为P<0.1和I>50%。我们将根据异质性大小使用固定效应模型或随机效应模型。
结果
由于评价正在进行，尚无结果可报告。
结论
本评价结果将为间接艾灸治疗AR的有效性和安全性提供可靠证据。
伦理与传播
本研究无需伦理批准。本系统评价和荟萃分析将在网上和纸质版上传播，以帮助指导临床医生。
PROSPERO注册号：CRD42019140944。
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