考来烯胺治疗迷走神经切断术后腹泻的双盲试验。
Double-blind trial of cholestyramine in post-vagotomy diarrhoea.
作者信息
Duncombe V M, Bolin T D, Davis A E
出版信息
Gut. 1977 Jul;18(7):531-5. doi: 10.1136/gut.18.7.531.
Abstract
The effect of cholestyramine in post-vagotomy diarrhoea has been assessed under double-blind conditions. Cholestyramine produced a significant improvement in frequency, urgency, and consistency of stool as well as episodic diarrhoea. Faecal bile acid excretion was significantly higher in the post-vagotomy group when compared with normal controls. These findings confirm the effectiveness of cholestyramine and support the concept of a bile acid mediated aetiology in post-vagotomy diarrhoea.
摘要
已在双盲条件下评估了消胆胺对迷走神经切断术后腹泻的疗效。消胆胺在改善大便频率、急迫感、稠度以及间歇性腹泻方面有显著效果。与正常对照组相比，迷走神经切断术后组的粪便胆汁酸排泄显著更高。这些发现证实了消胆胺的有效性，并支持胆汁酸介导的病因学在迷走神经切断术后腹泻中的概念。
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