糖尿病性腹泻时胆汁的改变。
Altered bile in diabetic diarrhoea.
作者信息
Molloy A M, Tomkin G H
出版信息
Br Med J. 1978 Nov 25;2(6150):1462-3. doi: 10.1136/bmj.2.6150.1462.
The size and composition of the bile-salt pools in a group of diabetics with neuropathy but no diarrhoea and a group with "diabetic diarrhoea" were compared with those in a group of stable, uncomplicated diabetics. The diabetics with neuropathy had significantly more dihydroxy bile salts, a larger bile-salt pool, and a higher faecal excretion of bile than the controls. The diabetics with diarrhoea had significantly more dihydroxy bile salts, a higher glycine to taurine ratio, a smaller bile-salt pool, and increased excretions of 14C-tracer and total bile salts. We conclude that considerable alterations occur in the bile of diabetics with neuropathy or diarrhoea, and we suggest that in some cases at least these abnormalities may indicate a mechanism for diabetic diarrhoea.
将一组患有神经病变但无腹泻的糖尿病患者、一组患有“糖尿病性腹泻”的患者的胆盐池大小和成分，与一组病情稳定、无并发症的糖尿病患者的胆盐池大小和成分进行了比较。患有神经病变的糖尿病患者比对照组具有显著更多的二羟基胆盐、更大的胆盐池以及更高的胆汁粪便排泄量。患有腹泻的糖尿病患者具有显著更多的二羟基胆盐、更高的甘氨酸与牛磺酸比例、更小的胆盐池以及14C示踪剂和总胆盐排泄量增加。我们得出结论，患有神经病变或腹泻的糖尿病患者的胆汁会发生相当大的改变，并且我们认为至少在某些情况下，这些异常可能表明糖尿病性腹泻的一种机制。
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