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[儿童系统性硬化症]

[Systemic scleroderma in children].

作者信息

Plantin P, Gavanou J, Le Fur J M, Guillet G

机构信息

Service de Dermatologie, C.H.U. Brest, Hôpital Morvan.

出版信息

Arch Fr Pediatr. 1988 Dec;45(10):805-8.

PMID:3266459
Abstract

A new case of systemic scleroderma in a child is reported. The frequency of this disease is much lower than focal scleroderma and than other connective diseases in childhood. Kidney and heart involvement is much less common than in adults. Raynaud's phenomenon and scleroderma however, as in this case, are often severe. The appropriate treatment has to be efficient towards sclerosis (D-penicillamine, corticosteroids), Raynaud's phenomenon (protection from cold, nifedipine) and other manifestations (prevention of gastric ulceration, physical therapy) and should consider every possible adverse effect on a growing organism.

摘要

报告了一例儿童系统性硬化症新病例。该疾病的发病率远低于局限性硬皮病以及儿童期的其他结缔组织疾病。与成人相比,肾脏和心脏受累情况要少见得多。然而,像本病例一样,雷诺现象和硬皮病往往较为严重。恰当的治疗必须对硬化症(D-青霉胺、皮质类固醇)、雷诺现象(防寒、硝苯地平)及其他表现(预防胃溃疡、物理治疗)有效,并且应考虑到对生长中的机体可能产生的每一种不良反应。

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