[非甾体抗炎药。V. 具有潜在抗炎作用的1-芳基-5-(1-吡咯基)-吡唑基-4-乙酸的合成]

[Nonsteroidal anti-inflammatory agents. V. Synthesis of 1-aryl-5-(1-pyrryl)-pyrazolyl-4-acetic acids with potential anti-inflammatory action].

作者信息

Corelli F, Massa S, Stefancich G, Silvestri R, Artico M, Pantaleoni G C, Palumbo G, Fanini D, Giorgi R

机构信息

Dipartimento di Studi Farmaceutici, Facolta' di Farmacia, Universita' di Roma La Sapienza.

出版信息

Farmaco Sci. 1988 Mar;43(3):251-65.

Abstract

The synthesis of 1-aryl-5-(1-pyrryl)pyrazoles bearing at position 4 an acetic or alpha-propionic chain is described. The new compounds can be structurally related to lonazolac and its analogues with analgesic-antiinflammatory activities. When tested pharmacologically in comparison with tolmetin and indomethacin none of the above derivatives showed any appreciable activity.

摘要

描述了在4位带有乙酸或α-丙酸链的1-芳基-5-(1-吡咯基)吡唑的合成。新化合物在结构上可能与具有镇痛抗炎活性的氯那唑酸及其类似物有关。当与托美丁和吲哚美辛进行药理测试比较时，上述衍生物均未显示出任何明显的活性。

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