Somoza G M, Yu K L, Peter R E
Department of Zoology, University of Alberta, Edmonton, Canada.
Gen Comp Endocrinol. 1988 Dec;72(3):374-82. doi: 10.1016/0016-6480(88)90159-1.
Effects of serotonin (5-HT) on serum gonadotropin (GtH) levels were studied in female and male goldfish, Carassius auratus L. Intraperintoneal (ip) administration of 5-HT (10 micrograms/g) produced a significant increase in serum levels of GtH at 0.5, 1, and 2 hr but not at 3-4 hours, after the drug was injected. Administration of different concentrations of 5-HT into the brain third ventricle (iv) did not affect serum GtH levels. In both sexes, the intraperitoneal administration of different doses of 5-HT (2.5-20 micrograms/g) caused a dose-dependent increase in serum GtH levels in fish at different gonadal stages; the greatest responses occurred in mature (= prespawning) fish. Fluoxetine (10 micrograms/g; ip), a 5-HT reuptake inhibitor, potentiated the stimulatory effects of 5-HT on GtH secretion. Ketanserin (10 micrograms/g; ip), a 5-HT antagonist, did not modify basal GtH levels; however, ketanserin blocked the 5-HT induced release of GtH. These results indicate that 5-HT has a stimulatory effect on GtH release in goldfish, most likely at the level of the pituitary gland.
研究了血清素（5-羟色胺，5-HT）对雌性和雄性金鱼（Carassius auratus L.）血清促性腺激素（GtH）水平的影响。腹腔注射5-HT（10微克/克）后0.5、1和2小时，血清GtH水平显著升高，但在注射药物后3 - 4小时未升高。向脑第三脑室注射不同浓度的5-HT不影响血清GtH水平。在两性中，腹腔注射不同剂量的5-HT（2.5 - 20微克/克）导致处于不同性腺阶段的金鱼血清GtH水平呈剂量依赖性升高；最大反应出现在成熟（=产卵前）的金鱼中。5-羟色胺再摄取抑制剂氟西汀（10微克/克；腹腔注射）增强了5-HT对GtH分泌的刺激作用。5-羟色胺拮抗剂酮色林（10微克/克；腹腔注射）不改变基础GtH水平；然而，酮色林阻断了5-HT诱导的GtH释放。这些结果表明，5-HT对金鱼GtH释放具有刺激作用，最有可能是在垂体水平。
