Delgado-Deida Yaritza, Alula Kibrom M, Theiss Arianne L
Division of Gastroenterology and Hepatology, Department of Medicine, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Gastroenterol Rep (Oxf). 2020 Jun 15;8(3):215-223. doi: 10.1093/gastro/goaa025. eCollection 2020 Jun.
Mitochondria are dynamic organelles that play a key role in integrating cellular signaling. Mitochondrial alterations are evident in all stages of tumorigenesis and targeting mitochondrial pathways has emerged as an anticancer therapeutic strategy. The Wnt-signaling pathway regulates many fundamental cellular functions such as proliferation, survival, migration, stem-cell maintenance, and mitochondrial metabolism and dynamics. Emerging evidence demonstrates that mitochondrial-induced regulation of Wnt signaling provides an additional mechanism to influence cell-fate decisions. Crosstalk between mitochondria and Wnt signaling presents a feedforward loop in which Wnt activation regulates mitochondrial function that, in turn, drives Wnt signaling. In this mini-review, we will discuss the recent evidence revealing the mitochondrial control of Wnt signaling and its implications for tumorigenesis and anticancer therapeutic targeting.
线粒体是动态细胞器，在整合细胞信号传导中起关键作用。线粒体改变在肿瘤发生的各个阶段都很明显，靶向线粒体途径已成为一种抗癌治疗策略。Wnt信号通路调节许多基本的细胞功能，如增殖、存活、迁移、干细胞维持以及线粒体代谢和动力学。新出现的证据表明，线粒体诱导的Wnt信号调节为影响细胞命运决定提供了另一种机制。线粒体与Wnt信号之间的串扰呈现出一个前馈环，其中Wnt激活调节线粒体功能，而线粒体功能又反过来驱动Wnt信号。在本综述中，我们将讨论最近揭示线粒体对Wnt信号的控制及其对肿瘤发生和抗癌治疗靶点影响的证据。
