Aaliyari-Serej Zeynab, Ebrahimi Ayyub, Barazvan Balal, Ebrahimi-Kalan Abbas, Hajiasgharzadeh Khalil, Kazemi Tohid, Baradaran Behzad
Department of Applied Cell Sciences, School of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Adv Pharm Bull. 2020 Jul;10(3):338-349. doi: 10.34172/apb.2020.042. Epub 2020 May 11.
Breast cancer with various biological diversity known as the common reason of death in the world and despite progress in novel therapeutic approaches, it faced with failure and recurrence in general. Recent clinical and preclinical statistics support cancer stem cells (CSCs) hypothesis and its similarities with normal stem cells. Evaluation of related paper conclude in significance finding in the further characterization of CSCs biology such as surface biomarkers, microenvironment regulatory molecules, cell signaling pathways, cell to cell transition and drug efflux pumps to overcome multidrug resistance and effective therapy. Emerging novel data indicate biological concepts in the base of unsuccessful treatment. A powerful understanding of the cell signaling pathways in cancer and CSCs topics can be led us to define and control treatment problems in cancer. More recently nano medicine based on drug delivery system modification and new implications on combinatorial therapy have been used to treat breast cancer effectively. The aim of this review is focus on CSCs as a potential target of cancer therapy, to overcome the limitation and problems of current therapeutic strategies in cancer.
乳腺癌具有多种生物学多样性，是全球常见的死亡原因，尽管新型治疗方法取得了进展，但总体上面临失败和复发。最近的临床和临床前统计数据支持癌症干细胞（CSCs）假说及其与正常干细胞的相似性。对相关论文的评估得出了重要发现，即在癌症干细胞生物学的进一步特征化方面，如表面生物标志物、微环境调节分子、细胞信号通路、细胞间转变和药物外排泵，以克服多药耐药性并实现有效治疗。新出现的数据表明了治疗失败背后的生物学概念。对癌症和癌症干细胞中细胞信号通路的深入理解可以引导我们定义和控制癌症治疗中的问题。最近，基于药物递送系统修饰的纳米医学以及在联合治疗中的新应用已被用于有效治疗乳腺癌。本综述的目的是聚焦于癌症干细胞作为癌症治疗的潜在靶点，以克服当前癌症治疗策略的局限性和问题。
