Identification and antigiardial activity of biocompounds produced in the mycelium in submerged fermentation.

Natural antiparasitic agents are used as a strategy for advances in the treatment of neglected tropical diseases (NTDs), such as giardiasis. The present paper identified the compounds produced by mycelium grown in submerged fermentation and investigated the antigiardial activity potential of extracts . mycelium crude extract () was obtained by the maceration process and after purification in column, thirty compounds were identified by gas chromatography - mass spectrometry (GC-MS) in hexane sub-fraction (). To determine the antigiardial potential, different parts of the purified have been evaluated, where hexane () and dichloromethane () fractions showed reduction levels higher than 90% of the trophozoites at 100 μg mL. This antigiardial activity was investigated aiming to explore the possibility of mycelium extract as a novel antigiardial compound to the treatment of human giardiasis.