Skopicheva V I, Skopichev V G, Teslenko L V, Nikol'skiĭ N N
Tsitologiia. 1988 Nov;30(11):1307-10.
Certain changes in human carcinoma A-431 are found by scanning electron microscopy. The early cell response to growth factor (after 10 minutes) involves a disappearance of microvilli, an appearance of ruffles and rounded cells, along with a decrease in cell attachment to the substrate. The cell surface changes correlate with the state of cytoskeleton elements: the material stained with iron hematoxylin is accumulated in ruffle formation sites. Retractional fibrils filled with the cytoskeleton material result from a decrease in the cell area.
通过扫描电子显微镜发现人类A-431癌细胞存在某些变化。细胞对生长因子的早期反应（10分钟后）包括微绒毛消失、出现褶皱和细胞变圆，同时细胞与底物的附着减少。细胞表面的变化与细胞骨架元件的状态相关：苏木精铁染色的物质在褶皱形成部位积累。细胞面积减小导致充满细胞骨架物质的收缩性纤维形成。
