[Changes in the surface topography of 3T3 cells as affected by epidermal growth factor and insulin].

Using scanning electron microscopy, a study was made of the surface topography of the Swiss 3T3 cells whose proliferation was arrested in the serum-less (0.5%) medium due to the application of the epidermal growth factor and insulin for, respectively, 10 and 30 minutes. The early cell response on the growth factors was diminishing the number of microvilli and appearance of plasma membrane invaginations. The degree of quiescent cell spreading under the action of the two above factors was different, since the epidermal growth factor, unlike insulin, induced cell reaction.