National Infection Service, Public Health England, Porton Down, Salisbury, Wiltshire SP4 0JG, UK.
J Gen Virol. 2020 Oct;101(10):1047-1055. doi: 10.1099/jgv.0.001470.
Type I interferon receptor knockout mice (strain A129) were assessed as a disease model of hantavirus infection. A range of infection routes (intramuscular, intraperitoneal and intranasal) were assessed using minimally passaged Seoul virus (strain Humber). Dissemination of virus to the spleen, kidney and lung was observed at 5 days after intramuscular and intraperitoneal challenge, which was resolved by day 14. In contrast, intranasal challenge of A129 mice demonstrated virus tropism to the lung, which was maintained to day 14 post-challenge. These data support the use of the A129 mouse model for future infection studies and the evaluation of interventions.
I 型干扰素受体敲除小鼠（A129 品系）被评估为汉坦病毒感染的疾病模型。使用最小传代的汉城病毒（Humber 株）评估了多种感染途径（肌内、腹腔内和鼻内）。在肌内和腹腔内挑战后 5 天观察到病毒向脾、肾和肺的传播，到第 14 天得到解决。相比之下，A129 小鼠的鼻内挑战显示病毒对肺有嗜性，在挑战后 14 天仍保持不变。这些数据支持将 A129 小鼠模型用于未来的感染研究和干预措施的评估。
