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腹部脓毒症病灶清除时间与脓毒症患者的死亡率。

Time to clearance of abdominal septic focus and mortality in patients with sepsis.

机构信息

Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.

出版信息

Rev Bras Ter Intensiva. 2020 Jun;32(2):245-250. doi: 10.5935/0103-507x.20200029. Epub 2020 Jun 24.

DOI:10.5935/0103-507x.20200029
PMID:32667437
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7405735/
Abstract

OBJECTIVE

To assess the relationship between time to focus clearance and hospital mortality in patients with sepsis and septic shock.

METHODS

This was an observational, single-center study with a retrospective analysis of the time to clearance of abdominal septic focus. Patients were classified according to the time to focus clearance into an early (≤ 12 hours) or delayed (> 12 hours) group.

RESULTS

A total of 135 patients were evaluated. There was no association between time to focus clearance and hospital mortality (≤ 12 hours versus > 12 hours): 52.3% versus 52.9%, with p = 0.137.

CONCLUSION

There was no difference in hospital mortality among patients with sepsis or septic shock who had an infectious focus evacuated before or after 12 hours after the diagnosis of sepsis.

摘要

目的

评估脓毒症和感染性休克患者焦点清除时间与住院死亡率之间的关系。

方法

这是一项观察性、单中心研究,对腹部感染焦点清除时间进行回顾性分析。根据焦点清除时间将患者分为早期(≤12 小时)或延迟(>12 小时)组。

结果

共评估了 135 例患者。焦点清除时间与住院死亡率之间无关联(≤12 小时与>12 小时):52.3%与 52.9%,p=0.137。

结论

在诊断为脓毒症后 12 小时之前或之后清除感染灶的脓毒症或感染性休克患者,其住院死亡率无差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9700/7405735/09954537d27b/rbti-32-02-0245-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9700/7405735/09954537d27b/rbti-32-02-0245-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9700/7405735/09954537d27b/rbti-32-02-0245-g01.jpg

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本文引用的文献

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The epidemiology of sepsis in Brazilian intensive care units (the Sepsis PREvalence Assessment Database, SPREAD): an observational study.巴西重症监护病房脓毒症的流行病学(脓毒症患病率评估数据库,SPREAD):一项观察性研究。
Lancet Infect Dis. 2017 Nov;17(11):1180-1189. doi: 10.1016/S1473-3099(17)30322-5. Epub 2017 Aug 17.
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Management of intra-abdominal infections: recommendations by the WSES 2016 consensus conference.
腹腔内感染的处理:WSES 2016 共识会议的建议。
World J Emerg Surg. 2017 May 4;12:22. doi: 10.1186/s13017-017-0132-7. eCollection 2017.
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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016.拯救脓毒症运动:脓毒症与脓毒性休克管理国际指南:2016版
Crit Care Med. 2017 Mar;45(3):486-552. doi: 10.1097/CCM.0000000000002255.
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The impact of early surgical intervention in free intestinal perforation: a time-to-intervention pilot study.早期手术干预对游离性肠穿孔的影响:一项干预时机的初步研究。
World J Emerg Surg. 2015 Nov 6;10:54. doi: 10.1186/s13017-015-0047-0. eCollection 2015.
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Time from admission to initiation of surgery for source control is a critical determinant of survival in patients with gastrointestinal perforation with associated septic shock.从入院到开始进行手术以控制感染源的时间是伴有感染性休克的胃肠道穿孔患者生存的关键决定因素。
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