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两例真性红细胞增多症患者的急性氧合器阻塞：应急策略。

Acute oxygenator occlusion in two cases of polycythemia vera: Bailout strategies.

作者信息

Kaiser Philipp, Zuckermann Andreas, Horvat Johann, Lederer Franz, Gisslinger Heinz, Gremmel Franz, Simon Paul, Wiedemann Dominik, Andreas Martin

机构信息

Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria.

Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria.

出版信息

J Card Surg. 2020 Oct;35(10):2835-2837. doi: 10.1111/jocs.14876. Epub 2020 Jul 15.

DOI:10.1111/jocs.14876
PMID:32668053
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7586822/
Abstract

Polycytemia vera (PV) is a rare myeloproliferative neoplasm associated with microcirculatory disturbances, thrombosis and bleeding. Patients suffering from PV have a high risk of perioperative adverse events, but the literature regarding on-pump procedures in PV patients is scarce. We report two cases of acute and severe oxygenator failure during cardiopulmonary bypass and present valid exit scenarios.

摘要

真性红细胞增多症（PV）是一种罕见的骨髓增殖性肿瘤，与微循环障碍、血栓形成和出血有关。患有PV的患者围手术期发生不良事件的风险很高，但关于PV患者体外循环手术的文献却很少。我们报告了两例在体外循环期间发生急性和严重氧合器故障的病例，并提出了有效的应对方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac4f/7586822/ce12e7b27c9f/JOCS-35-2835-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac4f/7586822/13c1893afc71/JOCS-35-2835-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac4f/7586822/ce12e7b27c9f/JOCS-35-2835-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac4f/7586822/13c1893afc71/JOCS-35-2835-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac4f/7586822/ce12e7b27c9f/JOCS-35-2835-g002.jpg

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Navigating polycythemia vera and factor X deficiency on cardiopulmonary bypass for coronary artery bypass grafting: a case report.冠状动脉搭桥术中体外循环下应对真性红细胞增多症和X因子缺乏症：一例报告
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本文引用的文献

1
Recommendations for the diagnosis and treatment of patients with polycythaemia vera.真性红细胞增多症患者的诊断和治疗建议。
Eur J Haematol. 2018 Jul 30. doi: 10.1111/ejh.13156.
2
Anesthetic management of a patient with polycythemia vera undergoing emergency repair of a type-A aortic dissection and concomitant coronary artery bypass grafting: a case report.真性红细胞增多症患者行A型主动脉夹层急诊修复术及同期冠状动脉旁路移植术的麻醉管理：一例报告
Korean J Anesthesiol. 2015 Dec;68(6):608-12. doi: 10.4097/kjae.2015.68.6.608. Epub 2015 Nov 25.
3
Massive intracardiac thrombosis during coronary artery bypass grafting surgery.
冠状动脉搭桥手术期间发生的巨大心内血栓形成。
Int J Crit Illn Inj Sci. 2015 Jan-Mar;5(1):56-8. doi: 10.4103/2229-5151.152347.
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Management of extensive intracardiac thombosis in a patient with polycythemia vera undergoing coronary artery bypass grafting.真性红细胞增多症患者行冠状动脉旁路移植术时广泛心内血栓形成的处理
J Card Surg. 2012 May;27(3):320-2. doi: 10.1111/j.1540-8191.2011.01383.x. Epub 2012 Jan 26.
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Coronary artery bypass grafting in a patient with polycythaemia rubra vera - a rare indication with a spectrum of complication: a case report.真性红细胞增多症患者的冠状动脉搭桥术——一种罕见适应证及一系列并发症：病例报告
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Postsurgery outcomes in patients with polycythemia vera and essential thrombocythemia: a retrospective survey.真性红细胞增多症和原发性血小板增多症患者的术后结局：一项回顾性调查。
Blood. 2008 Jan 15;111(2):666-71. doi: 10.1182/blood-2007-07-102665. Epub 2007 Oct 1.
8
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera.一种导致持续性信号传导的独特克隆性JAK2突变会引发真性红细胞增多症。
Nature. 2005 Apr 28;434(7037):1144-8. doi: 10.1038/nature03546.
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Thrombosis and haemorrhage in polycythaemia vera and essential thrombocythaemia.真性红细胞增多症和原发性血小板增多症中的血栓形成与出血
Br J Haematol. 2005 Feb;128(3):275-90. doi: 10.1111/j.1365-2141.2004.05277.x.
10
Efficacy and safety of low-dose aspirin in polycythemia vera.低剂量阿司匹林治疗真性红细胞增多症的疗效与安全性
N Engl J Med. 2004 Jan 8;350(2):114-24. doi: 10.1056/NEJMoa035572.