术前抗肿瘤坏死因子制剂在慢性袋炎中的再循环与治疗失败相关。
Recycling of Precolectomy Anti-Tumor Necrosis Factor Agents in Chronic Pouch Inflammation Is Associated With Treatment Failure.
机构信息
Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Division of Gastroenterology, Lille University Hospital, Lille, France.
出版信息
Clin Gastroenterol Hepatol. 2021 Jul;19(7):1491-1493.e3. doi: 10.1016/j.cgh.2020.07.008. Epub 2020 Jul 12.
Abstract
Despite improvements in medical management, 10%-15% of patients with ulcerative colitis (UC) require total proctocolectomy (TPC) with ileal pouch anal anastomosis (IPAA) for refractory disease. Acute pouchitis is the most common post-IPAA inflammatory condition, with cumulative incidence of 45% at 5 years. Up to 20%-30% of patients develop chronic pouch inflammation (CPI), categorized as antibiotic responsive, antibiotic refractory, or Crohn's disease-like (CDL)..
摘要
尽管在医学治疗方面取得了进展，但仍有 10%-15%的溃疡性结肠炎 (UC) 患者因难治性疾病需要进行全结肠直肠切除术 (TPC) 联合回肠储袋肛管吻合术 (IPAA)。急性储袋炎是 IPAA 术后最常见的炎症性疾病，5 年内累积发生率为 45%。多达 20%-30%的患者会出现慢性储袋炎症 (CPI)，分为抗生素反应性、抗生素难治性或类似克罗恩病 (CDL)。
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