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Recycling of Precolectomy Anti-Tumor Necrosis Factor Agents in Chronic Pouch Inflammation Is Associated With Treatment Failure.术前抗肿瘤坏死因子制剂在慢性袋炎中的再循环与治疗失败相关。
Clin Gastroenterol Hepatol. 2021 Jul;19(7):1491-1493.e3. doi: 10.1016/j.cgh.2020.07.008. Epub 2020 Jul 12.
2
Inflammatory Pouch Conditions Are Common After Ileal Pouch Anal Anastomosis in Ulcerative Colitis Patients.炎症性袋状结构在溃疡性结肠炎患者回肠贮袋肛管吻合术后很常见。
Inflamm Bowel Dis. 2020 Jun 18;26(7):1079-1086. doi: 10.1093/ibd/izz227.
3
Ileal Pouch Anal Anastomosis (IPAA) for colitis; development of Crohn's and Pouchitis.回肠贮袋肛管吻合术（IPAA）治疗结肠炎；发展为克罗恩病和贮袋炎。
Am J Surg. 2022 Jul;224(1 Pt B):453-458. doi: 10.1016/j.amjsurg.2022.01.018. Epub 2022 Jan 22.
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Suppurative granulomatous inflammation in the ileo-anal pouch.回肠肛管吻合术后脓性肉芽肿性炎症。
J Crohns Colitis. 2013 Jun;7(5):e186-8. doi: 10.1016/j.crohns.2012.07.007. Epub 2012 Jul 21.
5
An Update on the Medical Management of Inflammatory Pouch Complications.炎症性袋并发症的医学管理更新。
Am J Gastroenterol. 2020 Sep;115(9):1439-1450. doi: 10.14309/ajg.0000000000000666.
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Outcomes of Ileoanal Pouch Anastomosis in Pediatric Ulcerative Colitis Are Worse in the Modern Era: A Time Trend Analysis Outcomes Following Ileal Pouch-Anal Anastomosis in Pediatric Ulcerative Colitis.小儿溃疡性结肠炎直肠吻合口的结局在现代更差：小儿溃疡性结肠炎直肠吻合术后的时间趋势分析结果
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A prospective evaluation of the long-term outcome of ileal pouch-anal anastomosis in patients with inflammatory bowel disease-unclassified and indeterminate colitis.对炎症性肠病未分类和不确定性结肠炎患者回肠储袋肛管吻合术长期结局的前瞻性评估。
Dis Colon Rectum. 2009 May;52(5):872-8. doi: 10.1007/DCR.0b013e31819f5d4c.
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Clinical approach to diseases of ileal pouch-anal anastomosis.回肠储袋肛管吻合术相关疾病的临床处理方法
Am J Gastroenterol. 2005 Dec;100(12):2796-807. doi: 10.1111/j.1572-0241.2005.00278.x.
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Comparison of long-term outcomes of S and J pouches and continent ileostomies in ulcerative colitis patients with restorative proctocolectomy-experience in subspecialty pouch center.在专科造袋中心接受保留直肠结肠切除术的溃疡性结肠炎患者中，S袋和J袋与可控回肠造口术的长期结果比较。
J Crohns Colitis. 2014 Oct;8(10):1227-36. doi: 10.1016/j.crohns.2014.02.019. Epub 2014 Mar 20.
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Mucosal changes in ileal pouches after restorative proctocolectomy for ulcerative and Crohn's colitis.溃疡性结肠炎和克罗恩病行结直肠切除术后回肠储袋的黏膜变化
Dis Colon Rectum. 2000 Dec;43(12):1743-8. doi: 10.1007/BF02236861.

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1
Crohn's-like Ileal Pouch Illness and Ileal Pouch Salvage Strategies.克罗恩样回肠储袋疾病及回肠储袋挽救策略
Clin Colon Rectal Surg. 2024 May 10;38(2):160-168. doi: 10.1055/s-0044-1786384. eCollection 2025 Mar.
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Navigating Chronic Pouchitis: Pathogenesis, Diagnosis, and Management.慢性袋炎的诊治：发病机制、诊断与管理
Gastroenterol Hepatol (N Y). 2025 Jan;21(1):46-58.
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Pouchitis unveiled: exploring clinical features, diagnosis, and cutting-edge treatments.揭秘袋炎：探索临床特征、诊断及前沿治疗方法
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Medical Therapies for Prevention and Treatment of Inflammatory Pouch Disorders-A Systematic Review and Meta-Analysis.预防和治疗炎症性袋状疾病的医学疗法——一项系统评价和荟萃分析
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Mucosal Single-Cell Profiling of Crohn's-Like Disease of the Pouch Reveals Unique Pathogenesis and Therapeutic Targets.黏膜单细胞分析技术揭示了 pouch 克罗恩病的独特发病机制和治疗靶点。
Gastroenterology. 2024 Dec;167(7):1399-1414.e2. doi: 10.1053/j.gastro.2024.07.025. Epub 2024 Jul 30.
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The Natural History After Ileal Pouch-Anal Anastomosis for Ulcerative Colitis: A Population-Based Cohort Study From the United States.溃疡性结肠炎回肠贮袋-肛管吻合术后的自然史：来自美国的一项基于人群的队列研究。
Am J Gastroenterol. 2024 Nov 1;119(11):2267-2274. doi: 10.14309/ajg.0000000000002891. Epub 2024 Jun 18.
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AGA Clinical Practice Guideline on the Management of Pouchitis and Inflammatory Pouch Disorders.AGA 临床实践指南：关于 pouchitis 和炎症性 pouch 疾病的管理。
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Changes in Therapy Are Not Associated With Increased Remission in Patients With Crohn's Disease of the Pouch.造口处克罗恩病患者的治疗变化与缓解增加无关。
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The Rational Use of Advanced Therapies for Inflammatory Conditions of the Pouch.袋状炎性疾病的先进治疗方法的合理应用
Inflamm Bowel Dis. 2023 Dec 5;29(12):2007-2009. doi: 10.1093/ibd/izad264.
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Predictors of pouch failure: A tertiary care inflammatory bowel disease centre experience. pouch 失败的预测因素：三级炎症性肠病中心的经验。
Colorectal Dis. 2023 Jul;25(7):1469-1478. doi: 10.1111/codi.16589. Epub 2023 May 1.

本文引用的文献

1
Outcome of biological therapies in chronic antibiotic-refractory pouchitis: A retrospective single-centre experience.慢性抗生素难治性 pouchitis 中生物治疗的结果：回顾性单中心经验。
United European Gastroenterol J. 2019 Nov;7(9):1215-1225. doi: 10.1177/2050640619871797. Epub 2019 Aug 20.
2
Efficacy of Vedolizumab for Refractory Pouchitis of the Ileo-anal Pouch: Results From a Multicenter US Cohort.维多利珠单抗治疗回肠贮袋炎的疗效：来自美国多中心队列研究的结果。
Inflamm Bowel Dis. 2019 Aug 20;25(9):1569-1576. doi: 10.1093/ibd/izz030.
3
Ustekinumab Is Effective for the Treatment of Crohn's Disease of the Pouch in a Multicenter Cohort.乌司奴单抗治疗 pouch 克罗恩病的多中心队列研究
Inflamm Bowel Dis. 2019 Mar 14;25(4):767-774. doi: 10.1093/ibd/izy302.
4
Natural History of Adult Ulcerative Colitis in Population-based Cohorts: A Systematic Review.基于人群队列的成人溃疡性结肠炎自然史：系统评价。
Clin Gastroenterol Hepatol. 2018 Mar;16(3):343-356.e3. doi: 10.1016/j.cgh.2017.06.016. Epub 2017 Jun 16.
5
Previous Exposure to Multiple Anti-TNF Is Associated with Decreased Efficiency in Preventing Postoperative Crohn's Disease Recurrence.既往多次接触抗肿瘤坏死因子与预防克罗恩病术后复发的效率降低相关。
J Crohns Colitis. 2017 Mar 1;11(3):281-288. doi: 10.1093/ecco-jcc/jjw151.
6
Acute and chronic pouchitis--pathogenesis, diagnosis and treatment.急性和慢性袋炎——发病机制、诊断和治疗。
Nat Rev Gastroenterol Hepatol. 2012 Apr 17;9(6):323-33. doi: 10.1038/nrgastro.2012.58.
7
Outcome after proctocolectomy with ileal pouch-anal anastomosis for ulcerative colitis.溃疡性结肠炎行回肠贮袋肛管吻合术的直肠结肠切除术后结果。
Inflamm Bowel Dis. 2008 Jan;14(1):20-8. doi: 10.1002/ibd.20278.
8
Management of Crohn's disease of the ileoanal pouch with infliximab.英夫利昔单抗治疗回肠袋克罗恩病
Am J Gastroenterol. 2003 Oct;98(10):2239-44. doi: 10.1111/j.1572-0241.2003.07675.x.

术前抗肿瘤坏死因子制剂在慢性袋炎中的再循环与治疗失败相关。

Recycling of Precolectomy Anti-Tumor Necrosis Factor Agents in Chronic Pouch Inflammation Is Associated With Treatment Failure.

机构信息

Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.

Division of Gastroenterology, Lille University Hospital, Lille, France.

出版信息

Clin Gastroenterol Hepatol. 2021 Jul;19(7):1491-1493.e3. doi: 10.1016/j.cgh.2020.07.008. Epub 2020 Jul 12.

DOI:10.1016/j.cgh.2020.07.008
PMID:32668342
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8609533/
Abstract

Despite improvements in medical management, 10%-15% of patients with ulcerative colitis (UC) require total proctocolectomy (TPC) with ileal pouch anal anastomosis (IPAA) for refractory disease. Acute pouchitis is the most common post-IPAA inflammatory condition, with cumulative incidence of 45% at 5 years. Up to 20%-30% of patients develop chronic pouch inflammation (CPI), categorized as antibiotic responsive, antibiotic refractory, or Crohn's disease-like (CDL)..

摘要

尽管在医学治疗方面取得了进展，但仍有 10%-15%的溃疡性结肠炎 (UC) 患者因难治性疾病需要进行全结肠直肠切除术 (TPC) 联合回肠储袋肛管吻合术 (IPAA)。急性储袋炎是 IPAA 术后最常见的炎症性疾病，5 年内累积发生率为 45%。多达 20%-30%的患者会出现慢性储袋炎症 (CPI)，分为抗生素反应性、抗生素难治性或类似克罗恩病 (CDL)。