Cushman P, Gupta S, Grieco M H
Int J Addict. 1977 Apr;12(2-3):241-53. doi: 10.3109/10826087709027222.
Rosettes formed by circulating T and B lymphocytes obtained from 30 methadone maintained narcotic addicts were compared with those of 23 normal control subjects. Abnormal percentages of T rosette-forming cells were found in 6 of 30 patients (20%) while the percentages of B rosette-forming cells were increased in 40% and reduced in 27% of methadone patients. It appears that alterations in the percentages of peripheral lymphocytes, particularly those with cell surface complement receptors, should be added to the list of immunological abnormalities evident in some methadone-treated narcotic additics.
将从30名接受美沙酮维持治疗的吸毒成瘾者体内获取的循环T淋巴细胞和B淋巴细胞形成的玫瑰花结，与23名正常对照者的进行了比较。在30名患者中有6名（20%）发现T玫瑰花结形成细胞的百分比异常，而在美沙酮治疗患者中，40%的B玫瑰花结形成细胞百分比增加，27%的则减少。看来外周淋巴细胞百分比的改变，尤其是那些具有细胞表面补体受体的淋巴细胞百分比的改变，应被列入某些接受美沙酮治疗的吸毒成瘾者明显存在的免疫异常清单中。
