Bokor Janos, Krause Sandor, Torok Dora, Eszlari Nora, Sutori Sara, Gal Zsofia, Petschner Peter, Anderson Ian M, Deakin Bill, Bagdy Gyorgy, Juhasz Gabriella, Gonda Xenia
Department of Forensic and Insurance Medicine, Semmelweis University, Budapest, Hungary.
Nyírő Gyula National Institute of Psychiatry and Addictions, Budapest, Hungary.
Front Psychiatry. 2020 Jun 25;11:567. doi: 10.3389/fpsyt.2020.00567. eCollection 2020.
Suicide is an unresolved psychiatric and public health emergency, claiming 800,000 lives each year, however, its neurobiological etiology is still not understood. In spite of original reports concerning the involvement of in interaction with recent stress in the appearance of suicidal ideation and attempts, replication studies have yielded contradictory results. In our study, we analyzed the association between and lifetime suicide attempts, current suicidal ideation, hopelessness and thoughts of death as main effects, and in interaction with childhood adversities, recent stress, and different types of recent life events in a general population sample.
Two thousand and three hundred fifty-eight unrelated European volunteers were genotyped for , provided phenotypic data on previous suicide attempts, and current suicidal ideation, hopelessness and thoughts about death, and information on childhood adversities and recent life events. Logistic and linear regression models were run with age, gender, and population as covariates to test for the effect of as a main effect and in interaction with childhood adversities and recent life events on previous suicide attempts and current suicidal ideation. Benjamini-Hochberg FDR Q values were calculated to correct for multiple testing.
had no significant effect on lifetime suicide attempts either as a main effect on in interaction with childhood adversities. had a significant main effect on current suicidal ideation in the dominant model (Q=0.0344). did not interact with childhood adversities or total number of recent life events on any phenotypes related to current suicidal risk, however, a significant interaction effect between and current relationship problems emerged in the case of current suicidal ideation in the dominant model (Q=0.0218) and in the case of thoughts about death and dying in the dominant (Q=0.0094) and additive models (Q=0.0281).
While did not influence previous suicide attempts or interacted with childhood adversities, it did influence current suicidal ideation with, in addition, an interaction with recent relationship problems supporting the involvement of in suicide. Our findings that impacts only certain types of suicide risk-related behaviors and that it interacts with only distinct types of recent stressors provides a possible explanation for previous conflicting findings.
自杀是一个尚未解决的精神和公共卫生紧急情况，每年导致80万人死亡，然而，其神经生物学病因仍不清楚。尽管有关于[具体基因]与近期压力相互作用在自杀意念和自杀未遂出现中的作用的原始报告，但重复研究得出了相互矛盾的结果。在我们的研究中，我们分析了[具体基因]与终生自杀未遂、当前自杀意念、绝望和死亡想法之间的关联，这些作为主要影响因素，并分析了其与童年逆境、近期压力以及一般人群样本中不同类型近期生活事件的相互作用。
对2358名无亲属关系的欧洲志愿者进行了[具体基因]基因分型，提供了关于既往自杀未遂、当前自杀意念、绝望和死亡想法的表型数据，以及关于童年逆境和近期生活事件的信息。以年龄、性别和人群作为协变量运行逻辑回归和线性回归模型，以测试[具体基因]作为主要影响因素以及与童年逆境和近期生活事件相互作用对既往自杀未遂和当前自杀意念的影响。计算Benjamini-Hochberg FDR Q值以校正多重检验。
[具体基因]作为主要影响因素或与童年逆境相互作用时，对终生自杀未遂均无显著影响。[具体基因]在显性模型中对当前自杀意念有显著的主要影响（Q = 0.0344）。[具体基因]在与当前自杀风险相关的任何表型上，均未与童年逆境或近期生活事件总数相互作用，然而，在显性模型中当前自杀意念的情况下（Q = 0.0218）以及在显性（Q = 0.0094）和累加模型中关于死亡和濒死想法的情况下（Q = 0.0281），[具体基因]与当前关系问题之间出现了显著的相互作用效应。
虽然[具体基因]不影响既往自杀未遂或与童年逆境相互作用，但它确实影响当前自杀意念，此外，与近期关系问题的相互作用支持了[具体基因]与自杀有关。我们的研究结果表明，[具体基因]仅影响某些类型的自杀风险相关行为，并且仅与不同类型的近期应激源相互作用，这为先前相互矛盾的研究结果提供了一种可能的解释。
