Gonda Xenia, Petschner Peter, Eszlari Nora, Sutori Sara, Gal Zsofia, Koncz Szabolcs, Anderson Ian M, Deakin Bill, Juhasz Gabriella, Bagdy Gyorgy
Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary.
MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary.
Front Cell Neurosci. 2019 Apr 9;13:138. doi: 10.3389/fncel.2019.00138. eCollection 2019.
Environmental stress and its interaction with genetic variation are key contributors in the development of depression and anxiety, yet there is a failure to identify replicable genetic variants and gene-interaction effects in the background of these psychiatric symptoms. Recently it has been reported that and NOSI interact with financial but not other types of recent stressors in the development of depression. In the present study we investigated the interaction of rs3219151 and rs7766029 in interaction with different types of recent life events on the presence of depression and anxiety in a large general population sample. 2191 participants completed the List of Threatening Experiences questionnaire which covers four categories of stressful life events (financial problems, illness/personal problems, intimate relationships, and social network) experienced over the previous year and the Brief Symptom Inventory for depression and anxiety symptoms. Participants were genotyped for rs3219151 and rs7766029. Data were analyzed with linear regression models with age and gender as covariates. Results indicated that rs7766029 interacted significantly with financial but not other types of life events both in case of depression and anxiety symptoms. In contrast, rs3219151 showed a significant interaction with social network related life events in case of anxiety and with illness/personal problem-related life events in case of depression. Our results suggest that the psychological impact of different types of recent stress may be differentially modulated by distinct molecular genetic pathways. Furthermore, in case of certain genetic variants, the occurring psychiatric symptom may depend on the type of stress experienced.
环境压力及其与基因变异的相互作用是导致抑郁和焦虑的关键因素，然而在这些精神症状背景下，未能识别出可重复的基因变异和基因相互作用效应。最近有报道称，在抑郁症的发生过程中，[具体基因]与经济压力相互作用，但与其他类型的近期压力源无此相互作用。在本研究中，我们调查了[基因名称]rs3219151和[基因名称]rs7766029与不同类型的近期生活事件之间的相互作用，以及它们对一大群普通人群样本中抑郁和焦虑症状的影响。2191名参与者完成了威胁性经历清单问卷，该问卷涵盖了过去一年中经历的四类应激性生活事件（经济问题、疾病/个人问题、亲密关系和社交网络）以及抑郁和焦虑症状的简明症状量表。对参与者进行rs3219151和rs7766029基因分型。以年龄和性别作为协变量，用线性回归模型分析数据。结果表明，在抑郁和焦虑症状方面，[基因名称]rs7766029仅与经济压力而非其他类型的生活事件有显著相互作用。相比之下，[基因名称]rs3219151在焦虑方面与社交网络相关的生活事件有显著相互作用，在抑郁方面与疾病/个人问题相关的生活事件有显著相互作用。我们的结果表明，不同类型近期压力的心理影响可能由不同的分子遗传途径进行不同程度的调节。此外，对于某些基因变异，所出现的精神症状可能取决于所经历的压力类型。
