Bingham S A, Williams R, Cole T J, Price C P, Cummings J H
University of Cambridge & Medical Research Council, Dunn Clinical Nutrition Centre, UK.
Ann Clin Biochem. 1988 Nov;25 ( Pt 6):610-9. doi: 10.1177/000456328802500603.
One hundred and twenty two 24-h urine collections were obtained from a representative sample of men and women in the general population aged 25-44 years. The collections were verified for their completeness by urine recovery of oral doses of para-amino benzoic acid. Means (with 0.95 reference intervals) for both sexes for 24-h urinary output were determined for nitrogen, urea, creatinine, urate, ammonia, sodium, potassium, volume, and pH. Within person variation in nitrogen, urea, creatinine, ammonia, sodium and potassium was estimated for a consecutive 28-day series of 24-h urine collections for eight individuals. Within person variation was greatest for sodium and least for creatinine. These differences when compared with the between person variation in the analytes studied have implications for the precision with which a result from a single specimen can be used to place an individual within a distribution of values for epidemiological purposes. In clinical biochemistry, the population results reported here should be appropriate as a reference base for comparison with individual patient results.
从年龄在25至44岁的普通人群中具有代表性的男性和女性样本中收集了122份24小时尿液。通过口服对氨基苯甲酸后的尿液回收率来验证收集的完整性。测定了男女24小时尿量中氮、尿素、肌酐、尿酸盐、氨、钠、钾、体积和pH值的均值（以及0.95参考区间）。对8名个体连续28天的24小时尿液收集系列进行了氮、尿素、肌酐、氨、钠和钾的个体内变异估计。个体内变异钠最大，肌酐最小。与所研究分析物的个体间变异相比，这些差异对于单个样本结果用于将个体置于流行病学目的的数值分布中的精度具有影响。在临床生物化学中，此处报告的总体结果应适合作为与个体患者结果进行比较的参考基础。
