局部用溴芬酸对新生血管性年龄相关性黄斑变性视网膜内及视网膜下液的影响。
The Effect of Topical Bromfenac on Intraretinal and Subretinal Fluid in Neovascular Age-Related Macular Degeneration.
作者信息
Abdolrahimzadeh Solmaz, Fameli Valeria, Tizio Federico Di, Staso Federico Di, Fenicia Vito, Scuderi Gianluca
机构信息
Ophthalmology Unit, Neurosciences, Mental Health and Sensory Organs Department, St. Andrea Hospital, Sapienza University of Rome, Rome, Italy.
Ophthalmology Unit, Department of Sense Organs, Sapienza University of Rome, Rome, Italy.
出版信息
J Curr Ophthalmol. 2020 Apr 30;32(2):203-206. doi: 10.4103/JOCO.JOCO_105_20. eCollection 2020 Apr-Jun.
PURPOSE
To report the effect of topical bromfenac, a non-steroidal anti-inflammatory drug (NSAID), in a case of neovascular age-related macular degeneration (AMD).
METHODS
An 85-year-old woman presented with a complaint of visual acuity reduction in the right eye. Comprehensive ophthalmological examination and retinal imaging were performed.
RESULTS
Best corrected visual acuity was 2/100. Fundus examination showed reticular pseudodrusen and a small hemorrhage in the fovea. Fluorescein angiography showed an active neovascular membrane. Spectral-domain optical coherence tomography (SD-OCT) confirmed diagnosis and revealed subretinal and intraretinal fluid. The patient refused recommended intravitreal anti-vascular endothelial growth factor treatment and received topical bromfenac 0.09% twice daily. Follow-up with SD-OCT showed subretinal followed by intraretinal fluid reduction at 16 weeks after treatment.
CONCLUSION
Short-term reduction of subretinal and intraretinal fluid was observed with topical bromfenac monotherapy in neovascular AMD.
目的
报告局部应用非甾体抗炎药（NSAID）溴芬酸对1例新生血管性年龄相关性黄斑变性（AMD）的疗效。
方法
一名85岁女性因右眼视力下降前来就诊。进行了全面的眼科检查和视网膜成像。
结果
最佳矫正视力为2/100。眼底检查显示网状假性玻璃膜疣和黄斑区小出血。荧光素血管造影显示有活跃的新生血管膜。频域光学相干断层扫描（SD - OCT）确诊并显示视网膜下和视网膜内积液。患者拒绝推荐的玻璃体内抗血管内皮生长因子治疗，改为每天两次局部应用0.09%溴芬酸。SD - OCT随访显示治疗16周后视网膜下积液随后视网膜内积液减少。
结论
局部应用溴芬酸单药治疗新生血管性AMD可观察到视网膜下和视网膜内积液的短期减少。
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