Goldberg T E, Kleinman J E, Daniel D G, Myslobodsky M S, Ragland J D, Weinberger D R
Clinical Brain Disorders Branch, Neurosciences Research Center at St Elizabeths, Washington DC 20032.
Br J Psychiatry. 1988 Aug;153:187-90. doi: 10.1192/bjp.153.2.187.
Thirty-nine patients with DSM-III diagnoses of schizophrenia were examined for age disorientation, an inability to produce one's correct chronological age upon request. Six patients were age-disoriented and demented (as defined by Mini-Mental State evaluation), while two patients had delusions concerning their age, but were not demented. Age-disoriented, demented patients had very large cerebral ventricles and very low Mini-Mental State scores. This group differed on the cognitive and neuroanatomic variables from other demented, but not age-disoriented, patients, as well as from non-demented patients who were age-oriented. The age-disoriented patients appeared to be at an extreme end of the dementia spectrum in schizophrenia.
对39名被诊断为精神分裂症（依据《精神疾病诊断与统计手册》第三版）的患者进行了检查，评估他们是否存在年龄定向障碍，即被要求说出自己的实际年龄时无法正确作答。6名患者存在年龄定向障碍且患有痴呆（依据简易精神状态检查表定义），而2名患者有关于自己年龄的妄想，但未患痴呆。存在年龄定向障碍且患有痴呆的患者脑室非常大，简易精神状态检查表得分非常低。这组患者在认知和神经解剖学变量方面与其他患有痴呆但无年龄定向障碍的患者不同，也与年龄定向正常的非痴呆患者不同。存在年龄定向障碍的患者似乎处于精神分裂症痴呆谱系的极端情况。
