Woods B T, Yurgelun-Todd D, Benes F M, Frankenburg F R, Pope H G, McSparren J
Department of Neurology, Harvard Medical School, Boston, MA.
Biol Psychiatry. 1990 Feb 1;27(3):341-52. doi: 10.1016/0006-3223(90)90008-p.
Previous studies of long-term serial changes in ventricular size in schizophrenia (SCZ) have yielded mixed, albeit predominantly negative results. The current study examined ventricular changes in CT scans over intervals of 1-to 4 1/2 years in chronic schizophrenic and bipolar patients. The results indicated significant progression of ventricular size from initial to final scan in the schizophrenia group but not in the bipolar or control groups; the percent increase in VBR over baseline was 25% (p less than 0.01) in the schizophrenia group as compared with 11% (n.s.) in the bipolar group. The increases in ventricular enlargement in the schizophrenic group did not correlate with duration of illness but did appear to show an irregular stepwise pattern in several patients. It is concluded that progressive ventricular enlargement after onset of illness does occur in a subgroup of schizophrenic patients characterized by a chronic or deteriorating clinical course. The etiological implications of this finding are discussed.
先前关于精神分裂症（SCZ）患者心室大小长期系列变化的研究结果不一，不过主要为阴性结果。本研究对慢性精神分裂症患者和双相情感障碍患者在1至4.5年的时间间隔内CT扫描的心室变化进行了检查。结果表明，精神分裂症组从初次扫描到末次扫描心室大小有显著进展，而双相情感障碍组和对照组则无；精神分裂症组VBR（脑室脑比率）相对于基线的增加百分比为25%（p<0.01），而双相情感障碍组为11%（无统计学意义）。精神分裂症组心室扩大的增加与病程无关，但在部分患者中似乎呈现出不规则的逐步变化模式。得出的结论是，在以慢性或病情恶化为特征的精神分裂症患者亚组中，发病后确实会出现进行性心室扩大。本文讨论了这一发现的病因学意义。
