Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases, Beijing, China.
Adv Exp Med Biol. 2020;1207:487-494. doi: 10.1007/978-981-15-4272-5_36.
In recent years, diabetic kidney disease has been the main cause of end-stage renal disease; more and more people have faced this serious public health problem worldwide. Autophagy is a conserved multistep pathway that degrades and recycles damaged organelles and macromolecules to maintain intracellular homeostasis. Autophagy plays key roles in several diseases, including kidney diseases. It has been suggested that dysregulated autophagy plays a vital role in both glomerular and tubulointerstitial pathologies in kidneys under diabetic conditions. The advances in our understanding of autophagy in diabetic kidney disease will be helpful for us to discover a new therapeutic target for the prevention and treatment of this life-threatening diabetes complication.
近年来，糖尿病肾病已成为终末期肾病的主要病因；在世界范围内，越来越多的人面临这一严重的公共卫生问题。自噬是一种保守的多步骤途径，可降解和回收受损的细胞器和大分子，以维持细胞内的平衡。自噬在多种疾病中发挥关键作用，包括肾脏疾病。有研究表明，在糖尿病条件下，自噬失调在肾小球和肾小管间质病变中起着至关重要的作用。我们对糖尿病肾病中自噬的认识的提高，将有助于我们发现预防和治疗这种危及生命的糖尿病并发症的新治疗靶点。
