Wang Jing, Wang Xiaomin, Ma Tianpeng, Xie Yiqiang
Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Hainan Medical University, Haikou, Hainan, China.
Front Pharmacol. 2024 Jun 14;15:1390672. doi: 10.3389/fphar.2024.1390672. eCollection 2024.
Diabetic nephropathy (DN) constitutes a major microvascular complication of diabetes and is a primary cause of mortality in diabetic individuals. With the global rise in diabetes, DN has become an urgent health issue. Currently, there is no definitive cure for DN. , a Chinese herbal medicine traditionally used, exhibits a wide range of pharmacological effects and is frequently used in the prevention and management of DN. This paper offers an extensive review of the biological mechanisms by which delivers therapeutic advantages in DN management. These mechanisms include activating podocyte autophagy, regulating non-coding RNA, modulating gut microbiota, alleviating lipotoxicity, counteracting oxidative stress, and diminishing inflammatory responses, underscoring the therapeutic potential of in DN treatment.
糖尿病肾病(DN)是糖尿病的一种主要微血管并发症,也是糖尿病患者死亡的主要原因。随着全球糖尿病发病率的上升,DN已成为一个紧迫的健康问题。目前,DN尚无确切的治愈方法。[草药名称]是一种传统使用的中草药,具有广泛的药理作用,常用于DN的预防和管理。本文广泛综述了[草药名称]在DN管理中发挥治疗优势的生物学机制。这些机制包括激活足细胞自噬、调节非编码RNA、调节肠道微生物群、减轻脂毒性、对抗氧化应激和减轻炎症反应,突出了[草药名称]在DN治疗中的治疗潜力。