Department of Neurology, Mayo Clinic , Rochester, Minnesota, USA.
College of Biological Sciences, University of Minnesota , Minneapolis, MN, USA.
Neurocase. 2020 Oct;26(5):259-263. doi: 10.1080/13554794.2020.1795204. Epub 2020 Jul 16.
We report a patient presenting with clinical features of logopenic variant primary progressive aphasia (lvPPA) who was later diagnosed with probable dementia with Lewy bodies. LvPPA is a neurodegenerative disease that is characterized by anomia, word-finding difficulty, impaired comprehension, and phonological errors. The most common underlying pathology for lvPPA is Alzheimer's disease. However, our patient with clinical features of logopenic progressive aphasia was later diagnosed with probable dementia with Lewy bodies. This case demonstrates that lvPPA can also be an initial manifestation of a phenotype of dementia with Lewy bodies.
我们报告了一例以失语症变异型原发性进行性失语症（lvPPA）为临床特征的患者，后被诊断为可能的路易体痴呆。lvPPA 是一种神经退行性疾病，其特征为命名障碍、找词困难、理解障碍和语音错误。lvPPA 最常见的潜在病理是阿尔茨海默病。然而，我们这位以失语性进行性失语症为临床特征的患者后来被诊断为可能的路易体痴呆。这个病例表明，lvPPA 也可以是路易体痴呆表型的初始表现。
