Clarke Stephen, Hanna Donncha, Davidson Sarah, Shannon Ciarán, Mulholland Ciaran
School of Psychology, Queen's University Belfast, Belfast, UK.
Centre for Evidence and Social Innovation, Queen's University Belfast, Belfast, UK.
Early Interv Psychiatry. 2021 Aug;15(4):837-848. doi: 10.1111/eip.13020. Epub 2020 Jul 16.
To determine if poor sleep makes a unique contribution in predicting the likelihood of experiencing six or more attenuated psychotic symptoms and associated distress, after examining and controlling for sociodemographic factors, depression and drug/alcohol use.
An online survey was conducted using Amazon's online crowdsourcing service Mechanical Turk (MTurk). The sample was 1013 adults (18 to 36 years) from the general population in the United States. The survey consisted of the Prodromal Questionnaire 16 (PQ-16), the Pittsburgh Sleep Quality Index, the Patient Health Questionnaire 9, the Drug Abuse Screening Test 10 and the Alcohol Use Disorders Identification Test. Regression analyses were performed with the PQ-16 as the dependent variable, and sleep quality as the predictor variable, holding constant sociodemographic variables, depression, and alcohol/drug abuse.
37% of the sample endorsed six or more PQ-16 items, which may be suggestive of an at-risk mental state, with sleep disturbance significantly increasing the likelihood (Odds ratio 2.09 < .001) of endorsing six or more PQ-16 items. After controlling for sociodemographic variables, depression and drug/alcohol abuse, poor sleep quality made a unique contribution of 5.8% of the variance accounted for in level of distress experienced by attenuated psychotic symptoms.
Effective treatment of sleep disturbance may reduce the likelihood ofexperiencing attenuated psychotic symptoms and associated distress.
在检查并控制社会人口统计学因素、抑郁及药物/酒精使用情况之后，确定睡眠不佳在预测出现六种或更多精神病性症状减缓和相关痛苦可能性方面是否具有独特作用。
利用亚马逊的在线众包服务Mechanical Turk（MTurk）进行了一项在线调查。样本为来自美国普通人群的1013名成年人（18至36岁）。该调查包括前驱症状问卷16（PQ - 16）、匹兹堡睡眠质量指数、患者健康问卷9、药物滥用筛查测试10以及酒精使用障碍识别测试。以PQ - 16为因变量，睡眠质量为预测变量进行回归分析，同时保持社会人口统计学变量、抑郁以及酒精/药物滥用情况不变。
37%的样本认可六项或更多PQ - 16项目，这可能提示处于高危精神状态，睡眠障碍显著增加了认可六项或更多PQ - 16项目的可能性（优势比2.09，P < 0.001）。在控制了社会人口统计学变量、抑郁和药物/酒精滥用之后，睡眠质量差在精神病性症状减弱所经历的痛苦程度差异中占独特比例5.8%。
有效治疗睡眠障碍可能会降低出现精神病性症状减弱及相关痛苦的可能性。
