Rimmer Lara Jane, Moughal Saad, Bashir Mohamad
Vascular Surgery Department, 155510Royal Blackburn Teaching Hospital, Blackburn, UK.
Asian Cardiovasc Thorac Ann. 2020 Oct;28(8):512-519. doi: 10.1177/0218492320943350. Epub 2020 Jul 16.
Acute aortic syndrome is a group of interlinked conditions with common presenting symptoms, including aortic dissection, penetrating atherosclerotic ulcer, and intramural hematoma. Pharmacological management of acute aortic syndrome is a growing area, with key themes to address the underlying inflammatory pathways believed to be the cause. Research into interleukins, matrix metalloproteinases, and granulocyte macrophage colony-stimulating factor are just some of the many immunological properties being investigated and translated into medical therapies. Stem cell experiments may indicate further advances in the pathologies of acute aortic syndrome. The study of pharmacogenomics to improve treatment across different genomes is also a novel area outlined in this paper.
急性主动脉综合征是一组具有共同临床表现的相互关联的病症，包括主动脉夹层、穿透性动脉粥样硬化溃疡和壁内血肿。急性主动脉综合征的药物治疗是一个不断发展的领域，关键主题是解决被认为是病因的潜在炎症途径。对白介素、基质金属蛋白酶和粒细胞巨噬细胞集落刺激因子的研究只是众多正在研究并转化为医学疗法的免疫学特性中的一部分。干细胞实验可能表明急性主动脉综合征病理学方面的进一步进展。本文还概述了通过药物基因组学研究来改善不同基因组治疗效果这一新兴领域。
