Pan Zhifang, Zhang Xueming, Wang Xun, Deng Binbin, Zhang Wanli, Huang Huanjie
First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
First People's Hospital of Ning Yang, Taian 271000, China.
Parkinsons Dis. 2020 Jun 27;2020:6167989. doi: 10.1155/2020/6167989. eCollection 2020.
To observe and analyze the parameters of the sacral reflex and pudendal nerve somatosensory evoked potential (SSEP) in patients with multiple system atrophy (MSA) with respect to factors such as age, disease course, and subtype and provide evidence for the clinical diagnosis of MSA.
A total of 51 MSA patients and 30 healthy controls were selected from the First Affiliated Hospital of Wenzhou Medical University from May 2013 to November 2015. Electrophysiological sacral reflex detection and SSEP detection were performed using the Keypoint EMG/EP system. The extraction rate, latency, and amplitude of the sacral reflex and SSEP in the MSA group and control group were compared.
The sacral reflex latency and amplitude in patients with MSA were statistically different from those of the healthy controls. The latency of sacral reflex increases with the prolongation of the disease course, and the amplitude and initiation rate decrease with the prolongation of the disease course. There was no significant difference in sacral reflex latency and amplitude between MSA patients of different ages and subtypes. There was no significant difference in the latency or amplitude of SSEP between the MSA group and healthy control group.
The latency of sacral reflex increases with the prolongation of the disease course, and the amplitude and extraction rate decrease with the prolongation of the disease course. There was no significant difference in the parameters of sacral reflex between young MSA patients and elderly patients. And there was no statistically significant difference between MSA-P subtypes and MSA-C subtypes. This trial is registered with ISRCTNCR2009041.
观察并分析多系统萎缩（MSA）患者骶反射和阴部神经体感诱发电位（SSEP）的参数与年龄、病程、亚型等因素的关系，为MSA的临床诊断提供依据。
选取2013年5月至2015年11月在温州医科大学附属第一医院就诊的51例MSA患者和30例健康对照者。采用Keypoint肌电图/诱发电位系统进行骶反射电生理检测和SSEP检测。比较MSA组和对照组骶反射及SSEP的引出率、潜伏期和波幅。
MSA患者的骶反射潜伏期和波幅与健康对照者相比有统计学差异。骶反射潜伏期随病程延长而增加，波幅和引出率随病程延长而降低。不同年龄和亚型的MSA患者骶反射潜伏期和波幅无显著差异。MSA组与健康对照组SSEP的潜伏期和波幅无显著差异。
骶反射潜伏期随病程延长而增加，波幅和引出率随病程延长而降低。年轻MSA患者与老年患者骶反射参数无显著差异。MSA-P亚型和MSA-C亚型之间无统计学显著差异。本试验已在ISRCTNCR2009041注册。
