Noh Jin-Won, Kim Kyoung-Beom, Kwon Young Dae, Kim Jae Heon
Department of Health Administration, Dankook University, Cheonan, Korea.
Department of Humanities and Social Medicine, College of Medicine and Catholic Institute for Healthcare Management, The Catholic University of Korea, Seoul, Korea.
Transl Androl Urol. 2020 Jun;9(3):1135-1145. doi: 10.21037/tau-19-808.
Sodium intake is known to be related with hypertension (HTN), which could impact lower urinary tracts symptoms (LUTS) indirectly. To date, only limited clinical evidences exist upon the association between sodium preference and LUTS. This cross-sectional study analyzed the association between sodium preference and the severity of LUTS in men.
A cross-sectional analysis has been performed and a total of 86,637 participants among total registered population of 229,226 in Korean Community Health Survey (KCHS) were included for final analysis. The adjusted odds ratio (OR) or coefficient with 95% confidence interval (CI) estimates were described to show the association between sodium preference and LUTS using negative binomial regression (for the IPSS total, IPSS voiding, and IPSS storage symptoms), ordinal logistic regression (for the IPSS grade), and binomial logistic regression (for the IPSS nocturia symptoms).
Preference of salty taste group (high sodium preference) were significantly associated with higher IPSS total score (Coef =0.31; 95% CI: 0.27, 0.35), increased risk of severe IPSS grade (OR =1.46; 95% CI: 1.35, 1.57), higher IPSS voiding score (Coef =0.38; 95% CI: 0.32, 0.44), higher IPSS storage score (Coef =0.25; 95% CI: 0.22, 0.29), and increased risk of having IPSS nocturia symptoms (OR =1.21; 95% CI: 1.16, 1.27) compared to subjects with neutral group (normal sodium preference). Prediction of IPSS score according to salty taste preference showed u shaped distribution.
Sodium preference for taste were significantly associated with LUTS including voiding symptom, storage symptom and nocturia. Both higher and lower intake of sodium could be unfavorable factor for severity of LUTS.
已知钠摄入与高血压（HTN）相关，而高血压可能间接影响下尿路症状（LUTS）。迄今为止，关于钠偏好与下尿路症状之间的关联仅有有限的临床证据。这项横断面研究分析了男性钠偏好与下尿路症状严重程度之间的关联。
进行了一项横断面分析，韩国社区健康调查（KCHS）中229,226名登记人口中的86,637名参与者被纳入最终分析。使用负二项回归（用于国际前列腺症状评分（IPSS）总分、排尿症状和储尿症状）、有序逻辑回归（用于IPSS分级）和二项逻辑回归（用于IPSS夜尿症状）来描述调整后的优势比（OR）或系数以及95%置信区间（CI）估计值，以显示钠偏好与下尿路症状之间的关联。
与中性组（正常钠偏好）受试者相比，咸味偏好组（高钠偏好）与更高的IPSS总分（系数=0.31；95%CI：0.27，0.35）、严重IPSS分级风险增加（OR=1.46；95%CI：1.35，1.57）、更高的IPSS排尿评分（系数=0.38；95%CI：0.32，0.44）、更高的IPSS储尿评分（系数=0.25；95%CI：0.22，0.29）以及IPSS夜尿症状风险增加（OR=1.21；95%CI：1.16，1.27）显著相关。根据咸味偏好预测IPSS评分呈U形分布。
味觉上的钠偏好与包括排尿症状、储尿症状和夜尿在内的下尿路症状显著相关。钠摄入量过高或过低都可能是下尿路症状严重程度的不利因素。
