Department of Rheumatology, The First Affiliated Hospital of Zhengzhou University, 1 Eastern Jianshe Road, Zhengzhou, 450052, Henan, China.
Rheumatol Int. 2021 Jan;41(1):197-203. doi: 10.1007/s00296-020-04650-0. Epub 2020 Jul 16.
Nervous system involvement is a rare and serious complication of Behcet's disease (BD), and the peripheral type is rarer. This article aimed to describe a case of BD with the peripheral nervous system (PNS) involvement and present a comprehensive literature review. One case of BD with PNS involvement was reported and related literature was retrospectively reviewed via PubMed/MEDLINE and Scopus database. The patient was resistant to traditional treatments, such as glucocorticoids and immunosuppressants, but had rapid quiescence after using golimumab. Our literature review suggests that the involved peripheral nerves in BD were diverse, the most common were the tibial nerves and peroneal nerves, vasculitis might be the main cause, and prednisone was still the cornerstone of treatment. TNF-α inhibitors have been increasingly used for refractory BD in recent years. This well-illustrated case demonstrates the potential benefit of golimumab to the patient with PNS involvement. Given the diversity and complexity of PNS involvement, we recommend golimumab as a new trial treatment in clinical practice.
神经系统受累是白塞病（BD）罕见且严重的并发症，而周围型更为罕见。本文旨在描述一例伴有周围神经系统（PNS）受累的 BD 病例，并进行全面的文献复习。通过 PubMed/MEDLINE 和 Scopus 数据库，我们报告了 1 例 BD 伴 PNS 受累病例，并回顾性复习了相关文献。该患者对糖皮质激素和免疫抑制剂等传统治疗方法耐药，但使用戈利木单抗后迅速缓解。我们的文献复习表明，BD 中受累的周围神经多种多样，最常见的是胫神经和腓总神经，血管炎可能是主要原因，泼尼松仍然是治疗的基石。近年来，TNF-α 抑制剂越来越多地用于治疗难治性 BD。这个病例很好地说明了戈利木单抗对 PNS 受累患者的潜在益处。鉴于 PNS 受累的多样性和复杂性，我们建议在临床实践中试用戈利木单抗。
