Department of Neurology, Hirosaki University, Graduate School of Medicine, Hirosaki, Japan.
Department of Gastroenterology and Hematology, Hirosaki University, Graduate School of Medicine, Hirosaki, Japan.
J Neuroimmunol. 2021 May 15;354:577533. doi: 10.1016/j.jneuroim.2021.577533. Epub 2021 Mar 3.
Tumor necrosis factor-alpha (TNF-α) inhibitors are increasingly used for various autoimmune diseases. Demyelinating events in the CNS, including myelitis, are reportedly associated with TNF-α inhibitor exposure. Behcet's disease rarely involves the spinal cord. A 51-year-old Japanese woman presented with back pain, leg weakness, and numbness during golimumab administration, a TNF-α inhibitor, for Behcet's disease. Magnetic resonance imaging revealed multifocal myelitis in the cervical and thoracic spinal cords. Discontinuation of golimumab and steroid therapy were effective and the symptoms have not relapsed. Although it is possible that the patient's myelitis was part of the symptoms of neuro-Behcet's disease, we believe that golimumab likely played a role in the myelitis development.
肿瘤坏死因子-α（TNF-α）抑制剂越来越多地用于治疗各种自身免疫性疾病。据报道，中枢神经系统脱髓鞘事件，包括脊髓炎，与 TNF-α 抑制剂的暴露有关。贝赫切特病很少累及脊髓。一位 51 岁的日本女性在使用 TNF-α 抑制剂戈利木单抗治疗贝赫切特病时出现背痛、下肢无力和麻木。磁共振成像显示颈胸段脊髓多发性脊髓炎。停用戈利木单抗和类固醇治疗有效，症状未复发。虽然患者的脊髓炎可能是神经贝赫切特病症状的一部分，但我们认为戈利木单抗可能在脊髓炎的发展中起作用。
