Fan Haiyan, Hui Lingyun, Yan Xiaoting, Hou Wei, Bai E, Wang Li, Yu Xuewen
Department of Obstetrics & Gynecology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.
Department of General Medicine in Xi'an Jiaotong University, Xi'an, 710061, China.
BMC Womens Health. 2020 Jul 16;20(1):146. doi: 10.1186/s12905-020-01018-1.
Recent study found that vitamin D before conception was considered as a potential additional determinant for achieving pregnancy and live births. The study aimed to evaluate the serum 25 hydroxyvitamin D (25(OH)D) levels and its affecting factors among preconception fertile women.
This cross-sectional study enrolled 410 women aged 22-44 years who attended a preconception genetic counseling clinic from January 2018 to May 2019. Sociodemographic characteristics and reproductive history of women were collected, and height and weight were measured. Serum 25(OH)D concentration was assayed with chemiluminescence immunoassay. Descriptive statistics were used to examine serum 25(OH)D concentration, and socio-demographic characteristics and reproductive history among preconception women. Determinants of vitamin D deficiency and its affecting factors were assessed using χ2 test and logistic regression.
Findings showed 84.4% of women had serum 25(OH)D concentration below 20 ng/mL. Women working indoors as well as without a history of childbirth had significantly lower 25(OH)D levels compared with those non-working individuals and having delivered a previous child (both P < 0.05). The 25(OH)D levels were the lowest in winter among that in spring, summer, and autumn (all P < 0.001). Women in winter have significantly elevated OR of 5.00 (95%CI 1.75-14.25) to develop vitamin D deficiency. Seasonal variation in serum 25(OH)D levels was not present in non-working individuals and women aged 31-44 years.
Vitamin D deficiency is common among preconception women especially nulliparous women and working women, which propose to screen serum 25(OH)D on preconception evaluation and emphasize need vitamin D supplements and get sunshine exposure.
近期研究发现，孕前维生素D被认为是实现妊娠和活产的一个潜在额外决定因素。本研究旨在评估孕前可育女性的血清25羟维生素D（25(OH)D）水平及其影响因素。
这项横断面研究纳入了2018年1月至2019年5月期间到孕前遗传咨询门诊就诊的410名年龄在22 - 44岁的女性。收集了女性的社会人口学特征和生育史，并测量了身高和体重。采用化学发光免疫分析法检测血清25(OH)D浓度。使用描述性统计方法来分析孕前女性的血清25(OH)D浓度、社会人口学特征和生育史。使用χ2检验和逻辑回归评估维生素D缺乏的决定因素及其影响因素。
研究结果显示，84.4%的女性血清25(OH)D浓度低于20 ng/mL。与非在职女性和有过生育史的女性相比，从事室内工作以及无生育史的女性25(OH)D水平显著更低（均P < 0.05）。在春、夏、秋、冬四季中，冬季的25(OH)D水平最低（均P < 0.001）。冬季女性发生维生素D缺乏的OR值显著升高至5.00（95%CI 1.75 - 14.25）。非在职女性和31 - 44岁女性的血清25(OH)D水平不存在季节性变化。
维生素D缺乏在孕前女性中很常见，尤其是未生育女性和职业女性，这提示在孕前评估时应筛查血清25(OH)D，并强调需要补充维生素D和接受阳光照射。
